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Professor of Biology
Room 505NE
Phone:(718)951-5600 ex 1949
email: plipke@brooklyn.cuny.edu
Web Page Link:
Prof. Lipke
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Education
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Post-doctoral Fellow 1976-1978
Department of Zoology
University of Wisconsin, Maderson
Ph.D. (Biochemistry) 1977
University of California at Berkeley
B.S. (Chemistry) 1971
University of Chicago, Illinois
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Research Specialities
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Cell Adhesion in fungal life and pathogenesis;
baker's yeast sexual agglutinins
and
Candida albicans ALs proteins.
Cell surface architecture in yeast:
a novel drug target.
Bioinformatics and evolution in fungal cell walls.
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Selected Publications
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A few highlights from publications in major journals:
C o r o n a d o , J . , O . A t t i e , S . L . E p s t e i n , W . - G Q i u , a n d P . N . L i p k e . 2 0 0 6 . C o m p o s i t i o n - m o d i f i e d m a t r i c e s i m p r o v e i d e n t i f i c a t i o n o f h o m o l o g s o f S. c e r e v i s i a e l o w - c o m p l e x i t y g l y c o p r o t e i n s . E u k . C e l l 5 : i n p r e s s
K l o t z , S . A . , N . K . G a u r , J . R a u c e o , D . F . L a k e , Y . P a r k , K . S . H a h m , a n d P . N . L i p k e . 2 0 0 4 . A 2 3 - m e r P e p t i d e ( F n / 2 3 ) w i t h D u a l A n t i f u n g a l P r o p e r t i e s : I n h i b i t i o n o f A d h e r e n c e a n d K i l l i n g o f C a n d i d a a l b i c a n s . A n t i m i c r o b i a l A g e n t s C h e m o t h e r . 4 8 : 4 3 3 7 - 4 3 4 1 .
K i p n i s , P . , T h o m a s , N . , O v a l l e , R . a n d L i p k e , P . N . 2 0 0 4 . T h e v - S N A R E B e t 1 p i s r e q u i r e d f o r c e l l w a l l c r o s s - l i n k i n g o f S . c e r e v i s i a e a l p h a - A g g l u t i n i n . M i c r o b i o l o g y . 1 5 0 : 3 2 1 9 - 3 2 2 8 .
R a u c e o , J . , N . K . G a u r , J . E . E d w a r d s , S . A . K l o t z , K . - G . L e e , a n d P . N . L i p k e . 2 0 0 4 . G l o b a l C e l l - s u r f a c e C o n f o r m a t i o n a l S h i f t M e d i a t e d b y a C a n d i d a A d h e s i n I n f e c t . I m m u n . 7 2 : 4 9 4 8 - 4 9 5 5 .
K l o t z , S . A . , N . K . G a u r , D . F . L a k e , V . C h a n , J . R a u c e o , a n d P . N . L i p k e . 2 0 0 4 . A n a l y s i s o f B i n d i n g o f S m a l l P e p t i d e s b y C a n d i d a a l b i c a n s a n d S a c c h a r o m y c e s c e r e v i s i a e e x p r e s s i n g A d h e s i n s , A l a 1 / A l s 5 p o r A l s 1 p I n f e c t . I m m u n . 7 2 ( 4 ) : 2 0 2 9 - 3 4
J u e , C . K . a n d P . N . L i p k e . 2 0 0 2 . R o l e s o f F i g 2 p i n m a t i n g a n d a g g l u t i n a t i o n i n S a c c h a r o m y c e s c e r e v i s i a e . E u k . C e l l 1 : 8 4 3 - 8 4 5 .
S h e n , Z . M . , L . W a n g , J . P i k e , C . K . J u e , H . Z h a o , H . d e N o b e l , J . K u r j a n , a n d P . N . L i p k e . 2 0 0 1 . D e l i n e a t i o n o f F u n c t i o n a l R e g i o n s w i t h i n t h e S u b u n i t s o f t h e S a c c h a r o m y c e s c e r e v i s i a e C e l l A d h e s i o n M o l e c u l e a l p h a - A g g l u t i n i n . J . B i o l . C h e m . 2 7 6 : 1 5 7 6 8 - 1 5 7 7 5
Z h a o , H . , M . H . C h e n , Z . - M . S h e n , P . C . K a h n , a n d P . N . L i p k e . 2 0 0 1 . E n v i r o n m e n t a l l y - i n d u c e d c o n f o r m a t i o n a l s w i t c h i n g i n t h e y e a s t c e l l a d h e s i o n p r o t e i n , a l p h a - a g g l u t i n i n . P r o t e i n S c i e n c e 1 0 : 1 1 1 3 - 1 1 2 3
Z h a o , H . , Z . - M S h e n , P . C . K a h n , a n d P . N . L i p k e . 2 0 0 1 . I n t e r a c t i o n -A g g l u t i n i n a n d a l p h a - A g g l u t i n i n , S a c c h a r o m y c e s c e r e v i s i a e S e x u a l C e l l A d h e s i o n M o l e c u l e s . J . B a c t e r i o l . 1 8 3 : 2 8 7 4 - 2 8 8 0
O v a l l e , R . , C . S o l l , F . L i m , C . F l a n a g a n , T . R o t u n d a , a n d P . N . L i p k e . ( 2 0 0 1 ) . S y s t e m a t i c a n a l y s i s o f o x i d a t i v e d e g r a d a t i o n o f p o l y s a c c h a r i d e s u s i n g P A G E a n d H P L C / M S . C a r b o h y d r a t e R e s . 3 3 0 : 1 3 1 - 1 3 9 .
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Journal Reviewing
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- J . B a c t e r i o l o g y . E d i t o r i a l B o a r d 1 9 9 3 - 1 9 9 9
- P r o c . N a t l . A c a d . S c i .
- J . C e l l B i o l .
- M o l e c . C e l l B i o l .
- A n a l y t . B i o c h e m .
- J . I n t e r n a t . P e p t i d e R e s .
- M o l e c . M i c r o b i o l .
- E M B O J .
- F u n g a l G e n e t i c s a n d B i o l o g y
- E u k a r y o t i c C e l l
- J . C l i n i c a l M i c r o b i o l o g y
- F E M S M i c r o b i o l o g y L e t t e r s
- A n a l y t i c a l B i o c h e m .
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