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Home: Our Faculty: Brooklyn College Faculty:

Lesley Davenport

Professor   Department: Chemistry   Location: 344 Ingersoll Hall Extension   Phone: 718-951-5000 x2825   Fax: 718-951-4607   Email:   Lesley Davenport's Web site

Positions (selected): 2002-2008, Executive Officer, Biochemistry Ph.D. Program, Graduate Center of CUNY; 1998-present, Professor, Brooklyn College, CUNY; 1995-1996, Visiting Research Scientist, NIH; 1988-90 Visiting Research Fellow, Paterson Institute for Cancer Research & Medical Oncology, UK; 1988 Visiting Research Fellow, University of Utrecht, The Netherlands; 1985-1997, Associate/Assistant Professor, Brooklyn College; 1984-1985, Associate Research Scientist, The Johns Hopkins University; 1981-1983, Postdoctoral Research Fellow, The Johns Hopkins University. Education: DOCTOR OF PHILOSOPHY, UNIVERSITY OF SALFORD - 1981 (BIOCHEMISTRY) BSc (Hons), UNIVERSITY OF SALFORD, UK - 1977 (BIOCHEMISTRY) Areas of Expertise: Research in the laboratory is focused on studies of molecular interactions and fast conformational dynamics of large biomolecules. To carry out our studies, we use state-of-the-art fluorescence spectroscopic methods. Funded through the Brooklyn College NIH-Score grant, we are currently using sensitive fluorescence methodologies to investigate the folding and stability of telomeric DNA found at the end of chromosomes as an approach to designing better potential chemotherapeutics. Doctoral Rotation Projects: Students working in the laboratory will work as a member of a research team studying the dynamics and conformations of DNA G-quadruplexes. These structures are found within the telomeric DNA and inhibit telomerase, an enzyme that is important for tumorigenesis. We use state-of-the art spectroscopic methods for studying conformations of complex biomolecules including fluorescence spectroscopy and circular dichroism. Students will also gain experience in modern biochemical methods and experience in handling model DNA oligonucleotides. Books and Publications Liu, X.L., Kopkalli, Y., Vu, T., Hawkins, M.E., and Davenport, L. (2008) "Conformational Stability of Fluorescently Labeled Human Telomeric G-Quadruplexed DNA Sequences." Biophysical Journal 94, 289, Abstract. (Books and Publications: Abstract) 2008 Martinez, A., Rajapakse, Ch. S. K., Naoulou, B., Kopkalli, Y., Davenport, L. and Sanchez-Delgado, R.A. (2008) "The Mechanism of Antimalarial Action of the Ruthenium(II)-Chloroquine Complex [RuCl2(CQ)]2." Journal of Biological Inorganic Chemistry, DOI 10.1007/s00775-008-0356-9. (Books and Publications: Peer Reviewed Article) 2008 Rosales, T., Xu, J., Smirnov, A.V., Combs, C., Davenport, L., and Knutson, J.R. (2007) "Simultaneous Imaging of NAD+ and NADH Using CARS and 2-Photon Fluorescence Microscopy." Biophysical Journal, 90S, 156a, Abstract. (Books and Publications: Abstract) 2007 Davenport, L., Smirnov, A.V., Combs, C.A., Blinova, K., Knutson, J.R., and Balaban, R.S. (2006) 'Fluorescence Lifetime Imaging of NADH in Cells, in Solution and Encapsulated in Lipid Vesicles.' Biophysical Journal, 90S, 147a, Abstract. (Books and Publications: Abstract) 2006 Jamison, J.L., Davenport, L., and Williams, B. (2006) 'Solvatochromic in the Aromatic Ketone Benzo(b)Fluorenone.', Chem. Phys. Letts., 422, 30-35. (Books and Publications: Peer Reviewed Article) 2006 Kopkalli Y., Rosen, M.J., and Davenport, L. (2006) 'Interaction of N-Alkyl-2-Pyrrolidinone Surfactants with DMPC Lipid Bilayers.' Biophysical Journal, 90S, 505a, Abstract. (Books and Publications: Abstract) 2006 Kopkalli, Y., M.J. Rosen and Lesley Davenport. (2005) 'Interactions of N-alkyl-2-pyrrolidinone Surfactants with Dimyristoyilphosphatidylcholine Small Unilamellar Vesicles.', Biophysical Journal. 88, 70a, Abstract. (Books and Publications: Abstract) 2005 Kopkalli, Yasemin; Milton J. Rosen and Lesley Davenport. 'Interactions of n-alkyl-2-pyrrolidinone surfactants with llipid bilayers.' Department of Chemistry, The Graduate Center & Brooklyn College of the City University of New York, Brooklyn, NY, USA. Abstracts of Papers, 229th ACS National Meeting, San Diego, CA, US, March 13- 17, 2005 (2005), PHYS-489. Publisher: American Chemical Society, Washington D.C. CODEN: 69GQMP Conference; meeting Abstract written in English. AN 2005:193605 CAPLUS (Copyright (c) 2006 ACS on SciFinder (R)) (Books and Publications: Abstract) 2005 Ramsook, C., and Lesley Davenport (2005) 'Effect of Guanidine Hydrochloride and Urea on the Conformation of BPAO.' Bilophysical Journal 88, 38a, Abstract. (Books and Publications: Abstract) 2005 Voloshchuk, N., M.E. and Lesley Davenport. (2005) 'Mapping the DNA Binding Site of HIV-1 Integrase Using Fluorescent Oligonucleotides and Fluorescence Polarization.' Biophysical Journal 88, 406a, Abstract. (Books and Publications: Abstract) 2005 Awards, Honors and Fellowships Broeklundian Professor (2003-2008) (Awards and Honors) 2008 Editorial Board: Spectroscopy, 2000 - Present (Awards and Honors) 2008 NIH-MBRS SCORE, (1S06 GM060654 (076168)-010001) 4/1/08-3/31/09 "Conformational Stability and Dynamics of G-Quadruplexed DNA and Ligand Interactions", Role: Principal Investigator. The specific aims of this project are: 1) to map the conformational stability at specific sites within the G-quadruplex and to assess the effects of QIA binding on these parameters; and 2) to examine the underlying dynamics of intramolecular G-quadruplex folding and unfolding. (Grants and Fellowships) 2008 NIH-MBRS SCORE, (1S06 GM060654 (076168)-010001) 4/1/07-3/31/08, "Conformational Stability and Dynamics of G-Quadruplexed DNA and Ligand Interactions", Role: Principal Investigator. The specific aims of this project are: 1) to map the conformational stability at specific sites within the G-quadruplex and to assess the effects of QIA binding on these parameters; and 2) to examine the underlying dynamics of intramolecular G-quadruplex folding and unfolding. (Grants and Fellowships) 2007 NIH-MBRS SCORE, (1S06 GM060654 (076168)-010001) 4/1/06-3/31/07, "Conformational Stability and Dynamics of G-Quadruplexed DNA and Ligand Interactions", Role: Principal Investigator. The specific aims of this project are: 1) to map the conformational stability at specific sites within the G-quadruplex and to assess the effects of QIA binding on these parameters; and 2) to examine the underlying dynamics of intramolecular G-quadruplex folding and unfolding. (Grants and Fellowships) 2006 New York Academy of Sciences and MetroSection of AWIS: Outstanding Woman Scientist Award. (Awards and Honors) 2004 Outstanding Service Award, New York Section of the American Chemical Society (Awards and Honors) 2004 Chair & Service Award, New York Section of the American Chemical Society (Awards and Honors) 2003 Claire and Leonard Tow Professorship (2000-2002) (Awards and Honors) 2002 Conferences, Seminars and Symposiums Liu, X.L., Kopkalli, Y., Vu, T., Hawkins, M.E., and Davenport, L. (2008) "Conformational Stability of Fluorescently Labeled Human Telomeric G-Quadruplexed DNA Sequences." Annual Biophysical Society Meeting, Long Beach, USA, Poster. (Conferences, Seminars and Symposiums: Conference Presentation) 2008 Professional Leadership Executive Officer, Biochemistry PhD Program, The Graduate Center, CUNY (2002-2008) (Professional Leadership: Organizational Leadership Position) 2008 Councilor representing the New York Section, American Chemical Society (2003-2005) (Professional Leadership: Organizational Leadership Position) 2005 National Committee on Science (Affiliate Member), American Chemical Society (Professional Leadership: Committee Service) 2004 Chair of the New York Section of the American Chemical Society (Professional Leadership: Organizational Leadership Position) 2002 Chair, Biological Fluorescence Spectroscopy Subgroup, Biophysical Society (Professional Leadership: Organizational Leadership Position) 1999