Amy E. Ikui

  Asst Professor
  Department: Biology
  Location: 301c Ingersoll Hall Extension
  Phone: 718-951-5000 x2674
  Fax: 718-951-4659

  Email:

Our laboratory studies DNA replication and cell division using S. cerevisae as a model system. Our goal is to understand the molecular mechanism of cell growth control.

Education:
DOCTOR OF PHILOSOPHY, Albert Einstein College of Medicine - 2003 (BIOLOGY, CELL)

Areas of Expertise:
The cell cycle is an ordered set of processes by which one cell grows and divides into two daughter cells. Cell cycle progression is driven by Cyclin-Cdk complexes. Ikui's research studies the molecular targets of Cyclin-Cdk, and the biological importance of the new cyclin targets in S. cerevisiae.

Books and Publications
Ikui AE and Cross FR.
Specific genetic interactions between spindle assembly checkpoint proteins and B-type cyclins in Saccharomyces cerevisiae Genetics. 2009 Sep;183(1):51-61. (Books and Publications: Peer Reviewed Article) 2009

Ikui AE, Archambault V, Drapkin BJ, Campbell V, Cross FR.
Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition.
Genetics. 2007 Mar;175(3):1011-22. (Books and Publications: Peer Reviewed Article) 2007

Archambault V, Ikui AE, Drapkin BJ, Cross FR.
Disruption of mechanisms that prevent rereplication triggers a DNA damage response.
Mol Cell Biol. 2005 Aug;25(15):6707-21. (Books and Publications: Peer Reviewed Article) 2005

Ikui AE, Yang CP, Matsumoto T, Horwitz SB.
Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy.
Cell Cycle. 2005 Oct;4(10):1385-8. (Books and Publications: Peer Reviewed Article) 2005

Ikui AE, Furuya K, Yanagida M, Matsumoto T.
Control of localization of a spindle checkpoint protein, Mad2, in fission yeast.
J Cell Sci. 2002 Apr 15;115(Pt 8):1603-10. (Books and Publications: Peer Reviewed Article) 2002

Ikui AE, Yao Y, Zhou P, Weinstein IB.
Induction of apoptosis by sulindac sulfide in HL60 cells is enhanced by p21CiP1 or p27KiP1.
Anticancer Res. 2001 Jul-Aug;21(4A):2297-303. (Books and Publications: Peer Reviewed Article) 2001