- Basil, Jennifer
Areas of Expertise: Animal learning and memory, evolution of brain complexity, ecology, evolution, sensory biology, neural basis of behavior. I use invertebrate models, mostly.
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- Eshel, Dan
Areas of Expertise: The microtubule cytoskeleton and its motor proteins.
Our laboratory is studying signal transduction pathways that control and regulate the dynamics and function of microtubules in cells. The model organism used in the studies is the budding yeast. Work in the lab is performed by doctoral students and by undergraduate research students and it involves methods of molecular genetics and cell biology. Past and present funding sources include the American Cancer Society and the NIH.
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- Forest, Charlene
Areas of Expertise: In our lab, we are studing the cell and molecular biology of fertilization in algae.
To understand how gametes (sperm and egg) recognize and fuse with each other, we are cloning genes that prevent gamete fusion. Analysis of the proteins these gene code for will help us understand the types of proteins necessary for this process. We hope our studies will lead to a better understanding of the process of fertilization in other organisms, including humans.
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- Forlano, Paul M.
Areas of Expertise: Using fish as model systems, we employ a combination of evolutionary/systems neuroscience with a molecular and cellular approach in order to identify the mechanisms underlying steroid-induced neural plasticity and sex differences in brain and behavior. These studies focus on vocal, auditory and neuroendocrine circuits that are conserved across vertebrates.
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- Gavin, Ray
Areas of Expertise: Internalization of particulates through phagocytosis is of fundamental importance to diverse cell types including professional phagocytes of the immune system and microorganisms that use the process for capturing food. Internalized particulates are contained within intracellular structures known as vacuoles. Dr. Gavin investigates motility of phagocytic vacuoles. Specifically, the research focuses on Myo1, a novel myosin discovered in Dr. Gavin's laboratory.
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- He, Qi
Areas of Expertise: We are interested in understanding molecular mechanisms underlying the central nervous system development and a major effort has been devoted to identifying genes essential for neural specificity and interaction in the brain. Our approaches include a combination of molecular biology, confocal microscopic imaging, genetic maneuvering and transgenic methods.
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- Ikui, Amy E.
Areas of Expertise: The cell cycle is an ordered set of processes by which one cell grows and divides into two daughter cells. Cell cycle progression is driven by Cyclin-Cdk complexes. Ikui's research studies the molecular targets of Cyclin-Cdk, and the biological importance of the new cyclin targets in S. cerevisiae.
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- Lipke, Peter N.
Areas of Expertise: Glycoprotein structure and function; amyloids; cell adhesion proteins; bioinformatics; structure and biogenesis of fungal cell walls; molecular evolution in fungi; anti-fungal drug discovery; fungal pathogens in AIDS and immunosuppressed people
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- Muth, Theodore
Areas of Expertise: Microbiology - host pathogen interactions
Research Interests:
A. tumefaciens causes crown gall disease, a disease affecting several varieties of fruit trees and grapes. A. tumefaciens transfers virulence genes and proteins into susceptible host cells. The transferred virulence genes and proteins cause infected cells to form undifferentiated tumors. Recently this unique ability of A. tumefaciens to transform plants has been used by researchers to generate important transgenic crops.
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- Nishiura, James
Areas of Expertise: We study the developmental biology and genetics of mosquitoes. Cutting edge techniques of gene cloning, imaging and RNAi techniques are used to study the mechanisms that control mosquito metamorphosis. This information will be used to develop new and novel methods of controlling mosquito populations and mosquito borne diseases. They will also be used to investigate the evolution of cis acting elements that control gene expression during development.
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- Ovalle, Rafael
Areas of Expertise: Yeast Genetics and Physiology, Protein Purification, Carbohydrate Biochemistry
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- Polle, Juergen
Areas of Expertise: Dr. Polle is a leading expert in microalgae biotechnology. For the past 15 years he worked with various microalgae including unicellular green algae, diatoms, and cyanobacteria. Dr. Polle is internationally recognized for his work on algae of the genus Dunaliella. His research focuses on photosynthesis, secondary carotenoid biosynthesis, and biofuels production from microalgae. Dr. Polle's research was funded in the past for example by US DOE, NIH, and AFOSR.
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- Saxena, Anjana D.
Areas of Expertise: Nucleolin, a major phosphoprotein involved in ribosome biosynthesis, is often elevated in cancers and has been a useful marker for cancer diagnosis. We study the regulatory role of nucleolin on the tumor suppressor proteins (such as p14ARF and p53) as well as oncogenes (such as p53-antagonist Hdm2 and ARF-antagonist nucleophosmin).
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- Singh, Shaneen M.
Areas of Expertise: The long-term research goal of the lab is to apply computer modeling to gain insight into cellular signal transduction pathways, specifically to provide deeper insight into both the normal and aberrant subcellular targeting of domains contained in proteins which are part of macromolecular complexes and function in various biological processes.
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- Studamire, Barbara
Areas of Expertise: We analyze interactions between retroviral and host proteins using the tools of genetics, molecular biology and biochemistry. We are focusing primarily on the retroviral integrase protein and its interactions with host factors and chromatin.
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