Dan Eshel

  Professor
  Department: Biology
  Location: 300 Ingersoll Hall Extension
  Phone: 718-951-5000 x2015
  Fax: 718-951-4659

Email:

Dan Eshel's Web site

Dan Eshel got his Ph.D. degree in 1985 in chemistry at Ben Gurion University, studying the metachronal wave in ciliary tissues. With a Rothschild Postdoctoral Fellowship he moved to Caltech where he conducted theoretical analyses of sperm motility at the laboratory of Charles Brokaw. In 1987 he moved to the University of Hawaii to work with Ian Gibbons on the mechanical properties of sperm flagella and later was appointed as an Assistant Researcher at the Pacific Biomedical Research Center in Honolulu to initiate a study on the yeast cytoplasmic dynein. In 1993 Dr. Eshel moved to New York where he is currently on the biology faculty at Brooklyn College.

Education:
DOCTOR OF PHILOSOPHY, BEN GURION UNIVERSITY - 1985 (CHEMISTRY)

Areas of Expertise:
The microtubule cytoskeleton and its motor proteins.

Our laboratory is studying signal transduction pathways that control and regulate the dynamics and function of microtubules in cells. The model organism used in the studies is the budding yeast. Work in the lab is performed by doctoral students and by undergraduate research students and it involves methods of molecular genetics and cell biology. Past and present funding sources include the American Cancer Society and the NIH.

Books and Publications
Korolyev, E., Steinberg-Neifach, O. and Eshel, D. (2005) Mutations in the yeast kinesin-like Cin8p are alleviated by osmotic support. FEMS Micro. Let. 244: 379-383. (Books and Publications: Peer Reviewed Article) 2005

Steinberg-Neifach, O. and Eshel, D. (2002) Heterozygosity in MAT locus affects stability and function of microtubules in yeast. Biol. Cell 94: 147-156.

(Books and Publications: Peer Reviewed Article) 2002

Steinberg-Neifach, O., Braunstein, M.J. and Eshel, D. (2001) Rapid assessment of budding pattern by cell morphology in the yeast Saccharomyces cerevisiae. BioTech. 31: 482-486.

(Books and Publications: Peer Reviewed Article) 2001

Steinberg-Neifach, O. and Eshel, D. (2000) Simultaneous expression of both MAT loci in haploid cells suppresses mutations in yeast microtubule motor genes. Mol. Gen. Genet. 264: 300-305.

(Books and Publications: Peer Reviewed Article) 2000

Eshel, D. (1995) Functional Dissection of the dynein motor domain. Cell Motil. Cytoskel. 32: 133-135. (Books and Publications: Other Article) 1995

Saunders, W.S., Koshland, D., Eshel, D, Gibbons, I.R. and Hoyt, M.A. (1995) S. cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation. J. Cell Biol. 128: 617-624.

(Books and Publications: Peer Reviewed Article) 1995

Shingyoji, C., Yoshimura, K., Eshel, D., Takahashi, K. and Gibbons, I.R. (1995) Effect of beat frequency on the velocity of microtubule sliding in reactivated sea urchin sperm flagella under imposed head vibration. J. Exp. Biol. 198: 645-653.

(Books and Publications: Peer Reviewed Article) 1995

Eshel, D. Urrestarazu, L. A., Vissers, S., Jauniaux, J.-C., van Vliet-Reedijk, J.C., Planta, R.J. and Gibbons, I.R. (1993). Cytoplasmic dynein is required for normal nuclear segregation in yeast. Proc. Natl. Acad. Sci. USA 90: 11172-11176.

(Books and Publications: Peer Reviewed Article) 1993

Eshel, D., Shingyoji, C., Yoshimura, K., Gibbons, I.R. and Takahashi, K. (1992). The phase of sperm flagellar beating is not conserved over a brief imposed interruption. Exp. Cell Res. 202: 552-555.

(Books and Publications: Peer Reviewed Article) 1992

Murray J.M. and Eshel, D. (1992). Evanescent wave microscopy: a simple optical configuration. J. Microsc. 167: 49-62.

(Books and Publications: Peer Reviewed Article) 1992

Eshel, D., Shingyoji, C., Yoshimura, K., Gibbons, I.R. and Takahashi, K. (1991). Evidence for an inequality in the forces that generate principal and reverse bends in sperm flagella. J. Cell Sci. 100: 213-218.

(Books and Publications: Peer Reviewed Article) 1991

Takahashi, K., Shingyoji, C., Katada, J., Eshel, D. and Gibbons, I.R. (1991). Polarity in spontaneous unwinding after prior rotation of the flagellar beat plane in sea urchin spermatozoa. J. Cell Sci. 98: 183-189.

(Books and Publications: Peer Reviewed Article) 1991

Eshel, D., Shingyoji, C., Yoshimura, K., Gibbons, B.H., Gibbons, I.R. and Takahashi, K. (1990). Transient behavior of sea urchin sperm flagella following an abrupt change in beat frequency. J. Exp. Biol. 152: 441-451.

(Books and Publications: Peer Reviewed Article) 1990

Eshel, D. and Gibbons, I.R. (1989). External mechanical control of the timing of bend initiation in sea urchin sperm flagella. Cell Motil. Cytoskel. 14: 416-423.

(Books and Publications: Peer Reviewed Article) 1989

Eshel, D. and Brokaw, C.J. (1988). Determination of the average shape of flagellar bends. Cell Motil. Cytoskel. 9: 312-324.

(Books and Publications: Peer Reviewed Article) 1988

Ovadyahu, D., Eshel, D. and Priel, Z. (1988). Intensification of ciliary motility by extracellular ATP. Biorheol. 25: 489-502.

(Books and Publications: Peer Reviewed Article) 1988

Eshel, D. and Brokaw, C.J. (1987). New evidence for a 'biased baseline' mechanism for calcium-regulated asymmetry of flagellar bending. Cell Motil. Cytoskel. 7: 160-168.

(Books and Publications: Peer Reviewed Article) 1987

Eshel, D. and Priel, Z. (1987). Characterization of metachronal wave of beating cilia on frog's palate epithelium in tissue culture. J. Physiol. 388: 1-8. (Books and Publications: Peer Reviewed Article) 1987

Eshel, D. and Priel, Z. (1986). Spectral characterization of ciliary beating: Biological meaning of the spectral linewidth. Biophys. Chem. 23: 261-265.

(Books and Publications: Peer Reviewed Article) 1986

Eshel, D. and Priel, Z. (1986). Spectral characterization of ciliary beating: Temperature dependence of spectral parameters. Biophys. Chem. 25: 215-222. (Books and Publications: Peer Reviewed Article) 1986

Eshel, D., Grossman, Y. and Priel, Z. (1985). Spectral characterization of ciliary beating: Variations of frequency with time. Amer. J. Physiol. 249: C160-C165.

(Books and Publications: Peer Reviewed Article) 1985

Awards, Honors and Fellowships
Signaling pathways and microtubule function. National Institutes of Health #3R15GM065885-02S1, $39,580, 2009-2010. Administrative supplement under the American Reinvestment and Recovery Act. (Grants and Fellowships) 2009

Prof. Eshel was appointed as a member of the editorial board of the journal Biochemistry Insights (Awards and Honors) 2008

Signaling pathways and microtubule function. National Institutes of Health #2R15GM065885, $229,500, 2006-2009.

(Grants and Fellowships) 2006

Acquisition of flow cytometer for interdisciplinary research and undergraduate training. National Science Foundation, MRI grant (Dr. T.R. Muth, Co-PI), $212,582, 2005.

(Grants and Fellowships) 2005

Signaling pathways and microtubule function. National Institutes of Health #1R15GM065885, $146,665, 2002-2005.

(Grants and Fellowships) 2002

Self regulation of cytoplasmic dynein. American Cancer Society #RPG-97-011-01-CB, $310,000, 1997-2000.

(Grants and Fellowships) 1997

Cold Spring Harbor Laboratory Fellowship to attend the Yeast Genetics Course. $2,500. 1992. (Grants and Fellowships) 1992

Study of a putative cytoplasmic dynein in yeast. National Science Foundation, #SGER9216392, $46,841, 1992-1993.

(Grants and Fellowships) 1992

The Rothschild Postdoctoral Fellowship. $17,000. 1985-1986. (Grants and Fellowships) 1985