Steven Clarke

  Visiting Professor
  Department: Health and Nutrition Sciences
  Location:
  Phone:

My career has been a unique blend of experiences involving both academics and corporate life. I have been an academic laboratory leader as well as a laboratory leader in pharmaceutical research. My administrative experience is extensive and ranges from functioning as a department head at the University of Texas for a department of 40 faculty and 1500 students to being a Senior Director of Research for McNeil Nutritionals, a Johnson and Johnson company. My career goal is to apply my hybrid experience to pursuing my academic career.

Education:
DOCTOR OF PHILOSOPHY, MICHIGAN STATE UNIVERSITY - 1976 (Human Nutrition)

MASTER OF SCIENCE, Washinton State University - 1972 (Nutrition)

Areas of Expertise:
The leading cause of diabetes is excess body fat, in particular fat accumulation in the liver and skeletal muscle. My reserch has demonstrated that liver fat synthesis is specifically suppressed by dietary polyunsaturated fatty acids, the most potent of which comes from fish oils. Fish oil fatty acids exert their effects by coordinately down regulating genes of fat synthesis and upregulating genes of fat oxidation. How this occurs is our laboratory objectve.

Books and Publications
Seminar presentation on nutrient regulation of gene expression in obesity to the Columbia Obesity Research Center (2009).
(Books and Publications: Peer Reviewed Article) 2009

Reed, M.A., Pories, W., Chapman, W., Pender, J., Barakat, H., Gavin, T.P., Green, T., Tapscott, E., Shankley, N., Ho, R., Polidori, D., Clarke, S.D., Piccoli, S.P., Brenner-Gatti, L., and Dohm, G.L. (2008) The amelioration of Type 2 Diabetes Mellitus following gastric by-pass surgery. Diabetes 57: A739.
(Books and Publications: Peer Reviewed Article) 2008

Teran-Garcia, M, Adamson, AW, Yu, W, Rufo, C, Suchankova G, Dreesen, TD, Tekle, M, Clarke, SD and Gettys, TW. (equally contributed by the laboratories of Clarke and Gettys). Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c Biochem. J. (2007) 402, 591-600. (Books and Publications: Peer Reviewed Article) 2007

Adamson, A.W., Suchankova, Rufo, C., Nakamura, M.T., Teran-Garcia, M., Clarke, S.D., and Gettys, T. W. (2006) Hepatocyte nuclear factor-4a contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase. Biochem. J. 399, 1020-130.
Dreeesen, T.D., Tekle, M., Tang, C., Cho, H.P., Clarke, S.D., and Gettys, T.W. (2006) A newly discovered member of the fatty acid desaturase gene family: a non-coiding, antisense RNA gene to delta-5 desaturase. Prostaglandins Leukotrienes & Essential fatty acids (in press).
(Books and Publications: Peer Reviewed Article) 2006

McNeil, C. J., Finach, A.M., Page, K.R., Clarke, S.D., Ashworth, C.J., and McArdle, H.J. (2005) Reproduction 129, 757-763.
Suchankova, G. Tekle, M., Saha, A.K., Ruderman, N.B., Gettys, T.W., and Clarke, S.D. (2005) Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochem. Biophys. Res. Commun. 326, 851-858.
(Books and Publications: Peer Reviewed Article) 2005

Clarke, S.D. and Nakamura, M.T. (2004) Fatty acid synthesis and its regulation. Encylopedia Biological Chem. 2, 99-103.
Clarke, S.D. (2004) The multi-dimensional regulation of gene expression by fatty acids: Polyunsaturated fats as nutrient sensors. Curr. Opin. Lipidol. 15, 13-18.
Clarke, S.D. (2004) Influence of dietary components on gene expression. Nutrition Today, p. 40-45.
(Books and Publications: Chapter) 2004