R.H. Gavin

Education:

Ph.D., University of Iowa - 1968 (Zoology)

M.S., University of Iowa - 1964 (Zoology)

B.S., Howard University - 1962 (Zoology)

Areas of Expertise:

Internalization of particulates through phagocytosis is of fundamental importance to diverse cell types including professional phagocytes of the immune system and microorganisms that use the process for capturing food. Internalized particulates are contained within intracellular structures known as vacuoles. Gavin investigates motility of phagocytic vacuoles. Specifically, the research focuses on Myo1, a novel myosin discovered in his laboratory.

Books and Publications

Gotesman, M., S.A. Williams, J.A. Garcés and R.H. Gavin. "Chromosome Walking by Inverse PCR." PCR Technology: Current Innovations 3rd ed. Ed. T. Nolan. London: CRC Press. In press. (Books and Publications: Forthcoming Publications) 2013

Gotesman, Michael, Roland E. Hosein and R.H. Gavin. "MyTH4, Independent of Its Companion FERM Domain, Affects the Organization of an Intramacronuclear Microtubule Array and Is Involved in Elongation of the Macronucleus in Tetrahymena thermophila." Cytoskeleton 68: 220-36. (Books and Publications: Peer Reviewed Article) 2011

Gotesman, Michael, Roland E. Hosein and R.H. Gavin. "A FERM Domain in a Class XIV Myosin Interacts with Actin and Tubulin and Localizes to the Cytoskeleton, Phagosomes, and Nucleus in Tetrahymena thermophila." Cytoskeleton 62: 90-101. (Books and Publications: Peer Reviewed Article) 2010

Methods in Molecular Biology: Cytoskeleton Methods and Protocols 2nd edition, Volume 586. New York: Humana Press. ISBN-10: 1607613751; ISBN-13: 978-1607613756. (Books and Publications: Edited Book) 2009

Garcés, J., R.E. Hosein and R.H. Gavin. "MY01, a Class XIV Myosin, Affects Developmentally Regulated Elimination of the Macronucleus During Conjugation of Tetrahymena thermophila." Biology of the Cell 101: 393-400. (Books and Publications: Peer Reviewed Article) 2009

Hosein, R.E. and R.H. Gavin. "Myo1 Localizes to Phagosomes, Some of which Traffic to the Nucleus in a Myo1-Dependent Manner in Tetrahymena thermophila." Cell Motility Cytoskeleton 64: 926-35. (Books and Publications: Peer Reviewed Article) 2007

Hosein, R.E., S.A. Williams and R.H. Gavin. "Directed Motility of Phagosomes in Tetrahymena thermophila Requires Actin and Myolp, a Novel Unconventional Myosin." Cell Motility Cytoskeleton 61: 49-60. (Books and Publications: Peer Reviewed Article) 2005

Williams, S.A. and R.H. Gavin. "Myosin Genes in Tetrahymena thermophila." Cell Motility Cytoskeleton 61: 237-43. (Books and Publications: Peer Reviewed Article) 2005

Garcés, J.A., S.A. Williams and R.H. Gavin. "Chromosome Walking by Inverse PCR." PCR Technology: Current Innovations 2nd edition. Ed. T. Weissensteiner. London: CRC Press. (Books and Publications: Peer Reviewed Article) 2003

Hosein, R.E., S.A. Williams, K.A. Haye and R.H. Gavin. "Expression of GFP-Actin Leads to Failure of Both Nuclear Elongation and Cytokinesis in Tetrahymena thermophila." Journal of Eukot. Microbiology 50: 394-99. (Books and Publications: Peer Reviewed Article) 2003

"Myosins in Protists." International Review of Cytology 206. Ed. K.W. Jeon. New York: Academic Press. 97-134. (Books and Publications: Peer Reviewed Article) 2001

Methods in Molecular Biology: Cytoskeleton Methods and Protocols Volume 161. New Jersey: Humana Press. ISBN: 978-0-89603-771-7. (Books and Publications: Edited Book) 2000

Garcés, J.A. and R.H. Gavin. "Using an Inverse PCR Strategy to Clone Large, Contiguous Genomic DNA Fragments." Methods in Molecular Biology: Cytoskeleton Methods and Protocols 161. Ed. R.H. Gavin. New Jersey: Humana Press. 3-8. (Books and Publications: Peer Reviewed Article) 2000

Gavin, R.H., J.G. Hoey and J.A. Garcés. "Immunogold Electron Microscopy of Tetrahymena." Methods in Cell Biology: Tetrahymena thermophila 62. Eds. D.J. Asai and J.D. Forney. New York: Academic Press. 333-43. (Books and Publications: Peer Reviewed Article) 2000

Williams, S.A., R.E. Hosein, J.A. Garcés and R.H. Gavin. "MYO1, a Novel Unconventional Myosin Gene Affects Endocytosis and Macronuclear Elongation in Tetrahymena thermophila." Journal of Eukot. Microbiology 47: 561-68. (Books and Publications: Peer Reviewed Article) 2000

"Synergy of Cytoskeleton Components." Bioscience 49: 641-55. (Books and Publications: Peer Reviewed Article) 1999

Garcés, J.A. and R.H. Gavin. "A PCR Screen Identifies a Novel, Unconventional Myosin Heavy Chain Gene (MYO1) in Tetrahymena thermophila." Journal of Eukot. Microbiology 45: 252-59. (Books and Publications: Peer Reviewed Article) 1998

"Microtubule-Microfilament Synergy in the Cytoskeleton." International Review of Cytology 173. Ed. K.W. Jeon. New York: Academic Press. 207-42. (Books and Publications: Peer Reviewed Article) 1997

Garcés, J.A., J. Hoey and R.H. Gavin. "Putative Myosin Heavy and Light Chains in Tetrahymena: Co-localization to the Basal Body-Cage Complex and Association of the Heavy Chain with Skeletal Muscle Actin Filaments in Vitro." Journal of Cell Science 108: 869-81. (Books and Publications: Peer Reviewed Article) 1995

Hoey, J. and R.H. Gavin. "Localization of Actin in the Tetrahymena Basal Body-Cage Complex." Journal of Cell Science 103: 629-41. (Books and Publications: Peer Reviewed Article) 1992

Gavin, R.H. and W.A. Wilmot. "Antiserum Directed against Reassembled Basal Body Components." Invertebrate Reproduction & Development 17: 19-23. (Books and Publications: Peer Reviewed Article) 1990

Gavin, R.H., W.A. Duffus and P. Contard. "Characteristics of Basal Body Cartwheel Reassembly." Journal of Protozoology 36: 391-97. (Books and Publications: Peer Reviewed Article) 1989

Grimes, G. and R.H. Gavin. "Ciliary Protein Conservation during Development in the Ciliated Protozoan Oxytricha." Journal of Cell Biology 105: 2855-59. (Books and Publications: Peer Reviewed Article) 1987

Gambino, J., M.J. Ross, J.A. Weatherbee, R.H. Gavin and R.A. Eckhardt. "Xenopus Marginal Band Disassembly by Calcium Activated Cytoplasmic Factors." Journal of Cell Science 79: 199-215. (Books and Publications: Peer Reviewed Article) 1985

"In Vitro Reassembly of Basal Body Components." Journal of Cell Science 66:147-54. (Books and Publications: Peer Reviewed Article) 1984

Gambino, J., J.A. Weatherbee, R.H. Gavin and R.A. Eckhardt. "Studies on the Cytoskeleton and Nuclear Architecture of Xenopus Erythrocytes." Journal of Cell Science 72: 275-95. (Books and Publications: Peer Reviewed Article) 1984

"The Oral Apparatus of Tetrahymena. V. Oral Apparatus Polypeptides and Their Distribution." Journal of Cell Science 44: 147-54. (Books and Publications: Peer Reviewed Article) 1980

"The Oral Apparatus of Tetrahymena pyriformis. IV. Observations on the Organization of Microtubules and Filaments in the Isolated Oral Apparatus and the Differential Response by Microtubules to Potassium Chloride Extraction." Journal of Morphology 151: 239-58. (Books and Publications: Peer Reviewed Article) 1977

"The Oral Apparatus of Tetrahymena pyriformis. II. Cytochalasin B Inhibition of Oral Apparatus Morphogenesis." Journal of Experimental Zoology 197: 59-64. (Books and Publications: Peer Reviewed Article) 1976

"The Oral Apparatus of Tetrahymena pyriformis. III. The Binding of 3H-cytochalasin B by the Isolated Oral Apparatus." Journal of Experimental Zoology 197: 65-70. (Books and Publications: Peer Reviewed Article) 1976

"The Oral Apparatus of Tetrahymena pyriformis. I. Solubilization and Electrophoretic Separation of Oral Apparatus Proteins." Experimental Cell Research 85: 212-16. (Books and Publications: Peer Reviewed Article) 1974

Craven, G.R., R.H. Gavin and T.F. Fanning. "The Transfer RNA Binding Site of the 30s Ribosome and the Site of Tetracycline Inhibition." Cold Spring Harbor Symposia on Quantitative Biology 34: 129-37. (Books and Publications: Peer Reviewed Article) 1969

Gavin, R.H. and J. Frankel. "Macromolecular Synthesis, Diferentiation, and Cell Division in Tetrahymena pyriformis." Journal of Cellular Physiology 74: 123-34. (Books and Publications: Peer Reviewed Article) 1969

Gavin, R.H. and J. Frankel. "The Effects of Mercaptoethanol on Cellular Development in Tetrahymena." Journal of Experimental Zoology 161: 63-82. (Books and Publications: Peer Reviewed Article) 1966

"The Effects of Temperature on Development in Tetrahymena pyriformis." Journal of Protozoology 12: 307-18. (Books and Publications: Peer Reviewed Article) 1965

Awards, Honors and Fellowships

National Science Foundation, Grant # MCB-1121188, for "Function of an Unconventional Myosin in Tetrahymena." Principal investigator. $150,000; March 15, 2012-Feb. 28, 2014. (Grants and Fellowships) 2012

National Science Foundation Creativity Award for Outstanding Scientific Progress. (Awards and Honors) 2008

Claire and Leonard Tow Professor of Biology, 2006-08. (Awards and Honors) 2006

National Science Foundation Grant #DBI-0619460, for "Acquisition of a Confocal Microscope." Principal investigator. $202,127; Aug. 1, 2006-July 31, 2009. (Grants and Fellowships) 2006

Gordon Conference (Motile and Contractile Systems) Fellowship. (Grants and Fellowships) 2005

National Science Foundation, Grant # MCB-0517083, for "Function of an Unconventional Myosin in Tetrahymena." Principal investigator. $701,522; Aug. 1, 2005-July 31, 2012. Includes Special Creativity Extension Award ($281,532) in 2008. (Grants and Fellowships) 2005

National Science Foundation Grant # MCB-0130624, for "Function of an Unconventional Myosin in Tetrahymena." Principal investigator. $359,850. April 1, 2002-March 31, 2006. (Grants and Fellowships) 2002

National Science Foundation Grant # MCB-0110342, for "Function of an Unconventional Myosin in Tetrahymena." Principal investigator. $70,000; Aug. 1, 2001-July 31, 2002. (Grants and Fellowships) 2001

National Science Foundation Grant # MCB-9808301, for "Function of Myosins in Tetrahymena." Principal investigator. $326,000; July 1, 1998-June 30, 2001. (Grants and Fellowships) 2000

National Science Foundation Grant #MCB-9604137, for "Characterization of TETMYO-1, a Myosin Heavy Chain Gene in Tetrahymena." Principal investigator. $50,000; July 1, 1997-June 30, 1998. (Grants and Fellowships) 1997

Howard Hughes Medical Institute Biological Sciences Education Initiative, for "Partnerships in Science: Forging Links in Science Education." Project director. $1,200,000; 1996-2000. (Grants and Fellowships) 1996

National Science Foundation Grant #MCB-9631943, for "Actomyosin in a Basal Body-Associated Fibrillar Complex." Principal investigator. $50,000; July 1, 1996-June 30, 1997. (Grants and Fellowships) 1996

National Science Foundation; Grant #MCB-9301904, for "Actomyosin in a Basal Body-Associated Fibrillar Complex." Principal investigator. $244,263; July 1, 1993-Dec. 31, 1996. (Grants and Fellowships) 1993

Howard Hughes Medical Institute Biological Sciences Education Initiative, for "Improving Education in Science." Project director. $1,200,000; 1991-96. (Grants and Fellowships) 1991

National Science Foundation Grant #40507, for "Macromolecular Structure of the Oral Apparatus of Tetrahymena." Principal investigator. $40,000; Sept. 1, 1973-Feb. 29, 1976. (Grants and Fellowships) 1973

Research Activities

Research featured by National Science Foundation in an Aug. 10 press release. Available at http://nsf.gov/news/news_summ.jsp?cntn_id=109860&org=NSF&from=news. 2007

Conferences, Seminars and Symposiums

"Trafficking of Phagosomes in Tetrahymena." Ciliate Molecular Biology Conference. July 21-26. (Conferences, Seminars and Symposiums: Invited Talk) 2007

Gavin, R.H. and Jonathan Garcés. Poster. Annual meeting of the American Society for Cell Biology. Washington, D.C., Dec. 8-12. (Conferences, Seminars and Symposiums: Conference Presentation) 2007

Professional Leadership

Editorial board, Journal of Eukaryotic Microbiology, 2012-14. (Professional Leadership: Committee Service) 2012

Reviewer, National Science Foundation. (Professional Leadership: Committee Service) 2009

Reviewer, National Science Foundation. (Professional Leadership: Committee Service) 2008

Ad hoc reviewer for Cytoskeleton and Cell Motility, Cell Biology International, Biotechniques and Journal of Cell Science. (Professional Leadership: Committee Service) 2007

Member, grant proposal review panels, National Science Foundation, 1996-2008. (Professional Leadership: Committee Service) 2007

Editorial board, Journal of Eukaryotic Microbiology, 1999-2005. (Professional Leadership: Committee Service) 2005

Member, advisory board, International Review of Cell and Molecular Biology, 2004-15. (Professional Leadership: Committee Service) 2004

Program director, Cellular Systems Cluster, Division of Molecular and Cellular Biosciences, National Science Foundation. (Professional Leadership: Organizational Leadership Position) 2004