Dan Eshel
Professor
Health and Nutrition Sciences
Location: 4123 Ingersoll Hall
Phone: 718.951.5026
Fax: 718.951.4670
Email:
At Ben Gurion University, Dan Eshel studied the metachronal wave in ciliary tissues. With a Rothschild Postdoctoral Fellowship he moved to Caltech, where he conducted theoretical analyses of sperm motility at the laboratory of Charles Brokaw. In 1987 he moved to the University of Hawaii to work with Ian Gibbons on the mechanical properties of sperm flagella and later was appointed as an assistant researcher at the Pacific Biomedical Research Center in Honolulu to initiate a study on the yeast cytoplasmic dynein. In 1993 Eshel moved to New York, where he is professor of biology at Brooklyn College.
Education:
Ph.D., Ben Gurion University - 1985 (Chemistry)
Areas of Expertise:
The microtubule cytoskeleton and its motor proteins. Eshel's laboratory is studying signal transduction pathways that control and regulate the dynamics and function of microtubules in cells. The model organism used in the studies is the budding yeast. Work in the lab is performed by doctoral students and undergraduate research students, and it involves methods of molecular genetics and cell biology. Past and present funding sources include the American Cancer Society and the NIH.
Books and Publications
Shohat-Tal, A. and D. Eshel. "Cell Cycle Regulators Interact with Pathways that Modulate Microtubule Stability in Yeast." Eukaryotic Cell 10: 1705-13. (Books and Publications: Peer Reviewed Article) 2011
Korolyev, E., O. Steinberg-Neifach and D. Eshel. "Mutations in the Yeast Kinesin-Like Cin8p Are Alleviated by Osmotic Support." FEMS Microbiology Letters 244: 379-83. (Books and Publications: Peer Reviewed Article) 2005
Steinberg-Neifach, O. and D. Eshel. "Heterozygosity in MAT locus Affects Stability and Function of Microtubules in Yeast." Biol. Cell 94: 147-56. (Books and Publications: Peer Reviewed Article) 2002
Steinberg-Neifach, O., M.J. Braunstein and D. Eshel. "Rapid Assessment of Budding Pattern by Cell Morphology in the Yeast Saccharomyces cerevisiae." BioTech. 31: 482-86. (Books and Publications: Peer Reviewed Article) 2001
Steinberg-Neifach, O. and D. Eshel. "Simultaneous Expression of Both MAT loci in Haploid Cells Suppresses Mutations in Yeast Microtubule Motor Genes." Mol. Gen. Genet. 264: 300-05. (Books and Publications: Peer Reviewed Article) 2000
"Functional Dissection of the Dynein Motor Domain." Cell Motility and the Cytoskeleton 32: 133-35. (Books and Publications: Other Article) 1995
Saunders, W.S., D. Koshland, D. Eshel, I.R. Gibbons and M.A. Hoyt. "S. cerevisiae Kinesin- and Dynein-Related Proteins Required for Anaphase Chromosome Segregation." Journal of Cell Biology 128: 617-24. (Books and Publications: Peer Reviewed Article) 1995
Shingyoji, C., K. Yoshimura, D. Eshel, K. Takahashi and I.R. Gibbons. "Effect of Beat Frequency on the Velocity of Microtubule Sliding in Reactivated Sea Urchin Sperm Flagella Under Imposed Head Vibration." Journal of Experimental Biology 198: 645-53. (Books and Publications: Peer Reviewed Article) 1995
Eshel, D., L.A. Urrestarazu, S. Vissers, J.-C.Jauniaux, J.C. van Vliet-Reedijk, R.J. Planta and I..R. Gibbons. "Cytoplasmic Dynein Is Required for Normal Nuclear Segregation in Yeast." Proc. National Academy of Science USA 90: 11172-76. (Books and Publications: Peer Reviewed Article) 1993
Eshel, D., C. Shingyoji, K. Yoshimura, I.R. Gibbons and K. Takahashi. "The Phase of Sperm Flagellar Beating Is Not Conserved Over a Brief Imposed Interruption." Experimental Cell Research 202: 552-55. (Books and Publications: Peer Reviewed Article) 1992
Murray, J.M. and D. Eshel. "Evanescent Wave Microscopy: A Simple Optical Configuration." Journal of Microscopy 167: 49-62. (Books and Publications: Peer Reviewed Article) 1992
Eshel, D., C. Shingyoji, K. Yoshimura, I.R. Gibbons and K. Takahashi. "Evidence for an Inequality in the Forces that Generate Principal and Reverse Bends in Sperm Flagella." Journal of Cell Science 100: 213-18. (Books and Publications: Peer Reviewed Article) 1991
Takahashi, K., C. Shingyoji, J. Katada, D. Eshel and I.R. Gibbons. "Polarity in Spontaneous Unwinding after Prior Rotation of the Flagellar Beat Plane in Sea Urchin Spermatozoa." Journal of Cell Science 98: 183-89. (Books and Publications: Peer Reviewed Article) 1991
Eshel, D., C. Shingyoji, K. Yoshimura, B.H. Gibbons, I.R. Gibbons and K. Takahashi. "Transient Behavior of Sea Urchin Sperm Flagella Following an Abrupt Change in Beat Frequency." Journal of Experimental Biology 152: 441-51. (Books and Publications: Peer Reviewed Article) 1990
Eshel, D. and I.R. Gibbons. "External Mechanical Control of the Timing of Bend Initiation in Sea Urchin Sperm Flagella." Cell Motility and the Cytoskeleton 14: 416-23. (Books and Publications: Peer Reviewed Article) 1989
Eshel, D. and C.J. Brokaw. "Determination of the Average Shape of Flagellar Bends." Cell Motility and the Cytoskeleton 9: 312-24. (Books and Publications: Peer Reviewed Article) 1988
Ovadyahu, D., D. Eshel and Z. Priel. "Intensification of Ciliary Motility by Extracellular ATP." Biorheology 25: 489-502. (Books and Publications: Peer Reviewed Article) 1988
Eshel, D. and C.J. Brokaw. "New Evidence for a 'Biased Baseline' Mechanism for Calcium-Regulated Asymmetry of Flagellar Bending." Cell Motility and the Cytoskeleton 7: 160-68. (Books and Publications: Peer Reviewed Article) 1987
Eshel, D. and Z. Priel. "Characterization of Metachronal Wave of Beating Cilia on Frog's Palate Epithelium in Tissue Culture." Journal of Physiology 388: 1-8. (Books and Publications: Peer Reviewed Article) 1987
Eshel, D. and Z. Priel. "Spectral Characterization of Ciliary Beating: Biological Meaning of the Spectral Linewidth." Biophysical Chemistry 23: 261-65. (Books and Publications: Peer Reviewed Article) 1986
Eshel, D. and Z. Priel. "Spectral Characterization of Ciliary Beating: Temperature Dependence of Spectral Parameters." Biophysical Chemistry 25: 215-22. (Books and Publications: Peer Reviewed Article) 1986
Eshel, D., Y. Grossman and Z. Priel. "Spectral Characterization of Ciliary Beating: Variations of Frequency with Time." American Journal of Physiology 249: C160-65. (Books and Publications: Peer Reviewed Article) 1985
Awards, Honors and Fellowships
National Institutes of Health #3R15GM065885-02S1, for "Signaling Pathways and Microtubule Function." Administrative supplement under the American Reinvestment and Recovery Act; 2009-10. (Grants and Fellowships) 2009
Appointed to editorial board, Biochemistry Insights. (Awards and Honors) 2008
National Institutes of Health #2R15GM065885, for "Signaling Pathways and Microtubule Function." 2006-09. (Grants and Fellowships) 2006
National Science Foundation, MRI grant, for "Acquisition of Flow Cytometer for Interdisciplinary Research and Undergraduate Training." T.R. Muth, co-principal investigator. (Grants and Fellowships) 2005
National Institutes of Health #1R15GM065885, for "Signaling Pathways and Microtubule Function." 2002-05. (Grants and Fellowships) 2002
American Cancer Society #RPG-97-011-01-CB, for "Self-regulation of Cytoplasmic Dynein." 1997-2000. (Grants and Fellowships) 1997
Cold Spring Harbor Laboratory Fellowship, to attend the Yeast Genetics Course. (Grants and Fellowships) 1992
National Science Foundation, #SGER9216392, for "Study of a Putative Cytoplasmic Dynein in Yeast." 1992-93. (Grants and Fellowships) 1992
Rothschild Postdoctoral Fellowship, 1985-86. (Grants and Fellowships) 1985
