Education:
Post-doctoral Fellow, The Rockefeller University - 2008 (Yeast Genetics)
Ph.D., Albert Einstein College of Medicine - 2003 (Cell Biology)
Areas of Expertise:
The cell cycle is an ordered set of processes by which one cell grows and divides into two daughter cells. Cell cycle progression is driven by Cyclin-Cdk complexes. We recently discovered that Cyclin-Cdk and GSK-3 kinases control DNA replication in yeast. Ikui's research studies how DNA replication is controlled in order to maintain genome integrity.
Books and Publications
Ikui, A. E. "ORCA Is Regulated by Ubiquitin-mediated Degradation to Control Orc2 Function." Cell Cycle 3.11, November: 21. (Books and Publications: Other Article) 2012
Ikui, A.E., V. Rossio, L. Schroeder and S. Yoshida. "A Yeast GSK-3 Kinase Mck1 Promotes Cdc6 Degradation to Inhibit DNA Re-Replication." PLoS Genetics 8.12: e1003099. (Books and Publications: Peer Reviewed Article) 2012
Yang, C.P.H., L. Liu, A.E. Ikui and S.B. Horwitz. "The Interaction Between Mitotic Checkpoint Proteins, CENP-E and BubR1, Is Diminished in Epothilone B-resistant A549 Cells." Cell Cycle 9.6, March: 1207-13. (Books and Publications: Peer Reviewed Article) 2010
Ikui, A.E. and F.R. Cross. "Specific Genetic Interactions Between Spindle Assembly Checkpoint Proteins and B-type Cyclins in Saccharomyces Cerevisiae." Genetics 183.1, September: 51-61. (Books and Publications: Peer Reviewed Article) 2009
Ikui, A.E., V. Archambault, B.J. Drapkin, V. Campbell and F.R. Cross. "Cyclin and Cyclin-Dependent Kinase Substrate Requirements for Preventing Rereplication Reveal the Need for Concomitant Activation and Inhibition." Genetics 175.3, March: 1011-22. (Books and Publications: Peer Reviewed Article) 2007
Archambault, V., A.E. Ikui, B.J. Drapkin and F.R. Cross. "Disruption of Mechanisms that Prevent Rereplication Triggers a DNA Damage Response." Molecular Cell Biology 25.15, August: 6707-21. (Books and Publications: Peer Reviewed Article) 2005
Ikui, A.E., C.P. Yang, T. Matsumoto and S.B. Horwitz. "Low Concentrations of Taxol Cause Mitotic Delay Followed by Premature Dissociation of p55CDC from Mad2 and BubR1 and Abrogation of the Spindle Checkpoint, Leading to Aneuploidy." Cell Cycle 4.10, October: 1385-88. (Books and Publications: Peer Reviewed Article) 2005
Ikui, A.E., K. Furuya, M. Yanagida and T. Matsumoto. "Control of Localization of a Spindle Checkpoint Protein, Mad2, in Fission Yeast." Journal of Cell Science 115 (Part 8), Apr. 15: 1603-10. (Books and Publications: Peer Reviewed Article) 2002
Ikui, A.E., Y. Yao, P. Zhou and I.B. Weinstein. "Induction of Apoptosis by Sulindac Sulfide in HL60 Cells Is Enhanced by p21CiP1 or p27KiP1." Anticancer Research 21.4A, July-August: 2297-303. (Books and Publications: Peer Reviewed Article) 2001
Awards, Honors and Fellowships
NIH SC3 grant/PI:Ikui (2013-2017) (Grants and Fellowships) 2013
PSC CUNY enhanced award (Grants and Fellowships) 2013
PSC-CUNY enhanced award (Grants and Fellowships) 2012
NIH SC2 grant/PI:Ikui (2010-2013) (Grants and Fellowships) 2010
Charles Revson Postdoctoral Fellowship (Grants and Fellowships) 2004
Conferences, Seminars and Symposiums
Hunter College (CUNY) (Conferences, Seminars and Symposiums: Invited Talk) 2011
SUNY Downstate Medical Center (Conferences, Seminars and Symposiums: Invited Talk) 2011
International Cell Cycle and Development Meeting. Singapore (Conferences, Seminars and Symposiums: Invited Talk) 2010
York College (Conferences, Seminars and Symposiums: Invited Talk) 2010
