Education:
Ph.D., Syracuse University - 1987 (Physical Chemistry)
Areas of Expertise:
Dr. Dowd investigates the role of the protein osteocalcin in bone mineral properties during lead toxicity and low Mg2+ diets and conditions leading to diabetes. She is investigating bone mineral properties using FTIR imaging and microCT to deduce the mechanism behind bone fracture in various diseases. Dr. Dowd also conducts structural studies of osteocalcin to further understand the function of the protein in health and bone disorders.
Books and Publications
G. Yildirim, W.C. Budell, O. Berezovska, S. Yagerman, S.S. Maliath, P. Mastrokostas, S. Tommasini, T.L. Dowd, Lead induced differences in bone properties in osteocalcin +/+ and −/− female mice, Bone Reports 18 (2023) 101672. (Books and Publications: Article (Peer-reviewed)) 2023
Diegel CR, Hann S, Ayturk UM, Hu JCW, Lim KE, Droscha CJ, Madaj ZB, Foxa GE, Izaguirre I, Transgenics Core VVA, Paracha N, Pidhaynyy B, Dowd TL, Robling AG, Warman ML, Williams BO. An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet. 2020 May 28;16(5) (Books and Publications: Article (Peer-reviewed)) 2020
Berezovska O, Yildirim G, Budell WC, Yagerman S, Pidhaynyy B, Bastien C, van der Meulen MCH, Dowd TL.Osteocalcin affects bone mineral and mechanical properties in female mice. Bone. 2019 Nov;128:115031 (Books and Publications: Article (Peer-reviewed)) 2019
Bargiello TA, Oh S, Tang Q, Bargiello NK, Dowd TL, Kwon T.Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.Biochim Biophys Acta. 1860(1):22-39.
(Books and Publications: Article (Peer-reviewed)) 2018
Batir Y, Bargiello TA, Dowd TL. "NMR and structural data for Connexin 32 and Connexin 26 N-terminal peptides." Data Brief. 9:470-476.
(Books and Publications: Article (Peer-reviewed)) 2016
Batir Y, Bargiello TA, Dowd TL. (2016) "Structural studies of N-terminal mutants of Connexin 26 and Connexin 32 using (1)H NMR spectroscopy." Arch Biochem Biophys. 608:8-19. (Books and Publications: Article (Peer-reviewed)) 2016
Chan, K.L., I. Bakman, A.R. Marts, Y. Batir, T.L. Dowd, D.L. Tierney and B.R. Gibney. "Characterization of the Zn(II) binding properties of the human Wilms' tumor suppressor protein C-terminal zinc finger peptide." Inorganic Chemistry 53: 6309. (Books and Publications: Article (Peer-reviewed)) 2014
Kwan, T., T.L. Dowd and T.A. Bargiello. "The Carboxy Terminal Residues 220-283 Are Not Required for Voltage Gating of a Chimeric Connexin 32 Hemichannel." Biophysical Journal 105: 1376-82. (Books and Publications: Article (Peer-reviewed)) 2013
Malashkevich, V., S.C. Almo and T.L. Dowd. "The X-ray Crystal Structure of Bovine 3 Glu-Osteocalcin." Biochemistry 52: 8387. (Books and Publications: Article (Peer-reviewed)) 2013
Kalmatsky, B.D., Y. Batir, T.A. Bargiello and T.L. Dowd. "Structural Studies of N-terminal Mutants of Connexin 32 using (1)H NMR Spectroscopy." Archives of Biochemistry and Biophysics 526.1: 1-8.
(Books and Publications: Article (Peer-reviewed)) 2012
Morrill, G.A., T.L. Dowd, A.B. Kostellow and R.K. Gupta. "Progesterone-induced Changes in the Phosphoryl Potential During the Meiotic Divisions in Amphibian Oocytes: Role of Na/K-ATPase." BMC Developmental Biology 11: 67, Nov. 6. (Books and Publications: Article (Peer-reviewed)) 2011
Monir, A.U., C.M. Gundberg, S.E. Yagerman, M.C.H. van der Meulen, W.C. Budell, A.L. Boskey and T.L. Dowd. "The Effect of Lead on Bone Mineral Properties From Female Adult C57/BL6 Mice." Bone 47: 994-99. (Books and Publications: Article (Peer-reviewed)) 2010
Kalmatsky, B., S. Bhagan, Qingxiu Tang, T. Bargiello and T.L. Dowd. "Structural Studies of the N-terminus of Connexin 32 Using 1H NMR spectroscopy." Archives of Biochemistry and Biophysics 490: 9-16. (Books and Publications: Article (Peer-reviewed)) 2009
Tang, Qingxiu, Terry L. Dowd, Vytas K. Verselis and Thaddeus A. Bargiello. "Conformational Changes in a Pore Forming Region Underlie Voltage Dependent Loop-Gating for an Unapposed Connexin Hemichannel." Journal of General Physiology 133: 555-70. (Books and Publications: Article (Peer-reviewed)) 2009
Dowd, T.L., L. Li and C.M. Gundberg. "The 1H NMR Structure of Bovine Pb2+- Osteocalcin and Implications for Pb2+ Toxicity." Biochim. Biophys. Acta, Proteins and Proteomics 1784: 1534-15. (Books and Publications: Article (Peer-reviewed)) 2008
Awards, Honors and Fellowships
NIH 1RO1-GM098584-01A1, for "Structure-function Relation of Connexin Disease Mutations." Principal investigator. Sept. 1, 2012 - Aug. 31, 2016; $109,468 per year. In this grant I investigate structural alterations in the N-termini of Connexin gap junction molecules in diseases such as deafness, fatal skin disease and neuropathy. I use NMR spectroscopy to produce structural data of these molecules, which are then analyzed with functional data showing alterations in gap junctions observed in these diseases. The structural and functional data may provide insight into the etiology of these diseases as well as molecular mechanistic information on gap junction assembly and gating. (Grants and Fellowships) 2012
NIH GM46889, for "Structure-Function Studies of Gap Junctions" Terry Dowd, principal investigator, subcontract. $118,000 total direct costs, April 1, 2006-March 31, 2010. (Grants and Fellowships) 2006
NIH/NIEHS 2 R01 ES009032-06A2, for "The Effect of Pb2+ Toxicity at the Molecular Level." Principal investigator. $650,000 total direct costs; Dec. 1, 2004-Nov. 30, 2011. (Grants and Fellowships) 2004
Conferences, Seminars and Symposiums
Dowd, T., A. Boskey, C. Gundberg, M. Van der Meulen and O. Berezovska. "Lead-induced Differences in Bone Properties in Osteocalcin +/+ and -/- Female Mice." The American Society for Bone and Mineral Research. Houston. (Conferences, Seminars and Symposiums: Conference Presentation) 2014
"The High Resolution Xray Crystal Structure of Bovine 3 Glu Osteocalcin." International Conference on the Chemistry and Biology of Mineralized Tissues. Lake Geneva, Wis. (Conferences, Seminars and Symposiums: Invited Talk) 2013
"The Role of Osteocalcin on the Toxic Effect of Lead on Bone Properties." International Conference on the Chemistry and Biology of Mineralized Tissues in Carefree, Az. Berezovska, O., Budell, W., Gunhdberg, C.M., Ul Monir, A., van der Meulen, M.C.H., Boskey, A.L. and Dowd, T.L.
(Conferences, Seminars and Symposiums: Conference Presentation) 2010
Ul Monir, A., S.E. Yagerman, M.C.H. van der Meulen, C.M. Gundberg, A.L. Boskey and T.L. Dowd. "The Effect of Lead on Bone Mineral Properties from Female Adult C57/BL6 Mice." American Society for Bone and Mineral Research. Montreal 23: S410, M146. (Conferences, Seminars and Symposiums: Conference Presentation) 2008
Li, L., C.M. Gundberg and T.L. Dowd. "The Three-Dimensional 1H NMR Structure of Bovine Lead Ion-Bound Osteocalcin and Implications for Lead Toxicity." American Society for Bone and Mineral Research. Honolulu, 22 (S1): S163, M159. (Conferences, Seminars and Symposiums: Conference Presentation) 2007
