Amy E. Ikui

Education:

Post-doctoral Fellow, The Rockefeller University - 2008 (Yeast Genetics)

Ph.D., Albert Einstein College of Medicine - 2003 (Cell Biology)

Areas of Expertise:

Project 1: Determine how DNA replication is regulated by Cdk1 and phosphatases
Project 2: Determine the mechanism of cell size sensing in yeast and human cells
Project 3: DNA replication control in plants

Full publication list:

https://www.ncbi.nlm.nih.gov/myncbi/10KNrxmBy7yQo/bibliography/public/

Books and Publications

Philip J, Ord M, Silva A, Singh S, Diffley JFX, Remus D, Loog M, Ikui AE. Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14 and Sic1 for origin licensing in S. cerevisiae. eLife (2022) in press (BioRxiv: https://www.biorxiv.org/content/10.1101/2021.09.14.460335v1.full)
(Books and Publications: Article (Peer-reviewed)) 2022

Ikui AE, Ueki N, Kresti P and Cross FR. Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii. PLOS Genetics. (2021) https://doi.org/10.1371/journal.pgen.1009471 (Books and Publications: Article (Peer-reviewed)) 2021

Khondker S, Kajjo S, Chandler-Brown D, Skotheim J, Rudner A and Ikui AE*. PP2ACdc55 dephosphorylates Pds1 to inhibit spindle elongation. Journal of Cell Science (2020) 133(14) jcs243766. doi: 10.1242/jcs.243766 (Books and Publications: Article (Peer-reviewed)) 2020

Shroeder L and Ikui AE*. Tryptophan confers resistance to SDS-associated cell membrane stress in Saccharomyces cerevisiae PLOS One (2019) 14 (3): e0199484 doi: 10.1371/journal.pone.0199484 (Books and Publications: Article (Peer-reviewed)) 2019

Kono K and Ikui AE. "A new cell cycle checkpoint senses plasma membrane/cell wall damage in budding yeast" BioEssays 10.1002/bies.201770041 (Books and Publications: Article (Peer-reviewed)) 2017

Kono K, Al-Zain A, Schroeder L, Nakanishi M and Ikui AE*. "Plasma membrane/cell wall perturbation activates a novel cell cycle checkpoint during G1 in S. cerevisiae" PNAS 113(25) 6910-6915 (Books and Publications: Article (Peer-reviewed)) 2016

Al-Zain, A., L. Schroeder, A. Sheglov and Ikui AE. "Cdc6 Degradation Requires Phospho-degron Created by GSK-3 and Cdk1 for SCFCdc4 Recognition in S. cerevisiae." Molecular Biology of the Cell 26.14: 2609-19. (Books and Publications: Forthcoming Publications) 2015

"ORCA Is Regulated by Ubiquitin-mediated Degradation to Control Orc2 Function." Cell Cycle 3.11, November: 21. (Books and Publications: Article (Other)) 2012

Ikui, A.E., V. Rossio, L. Schroeder and S. Yoshida. "A Yeast GSK-3 Kinase Mck1 Promotes Cdc6 Degradation to Inhibit DNA Re-Replication." PLoS Genetics 8.12: e1003099. (Books and Publications: Article (Peer-reviewed)) 2012

Yang, C.P.H., L. Liu, A.E. Ikui and S.B. Horwitz. "The Interaction Between Mitotic Checkpoint Proteins, CENP-E and BubR1, Is Diminished in Epothilone B-resistant A549 Cells." Cell Cycle 9.6, March: 1207-13. (Books and Publications: Article (Peer-reviewed)) 2010

Ikui, A.E. and F.R. Cross. "Specific Genetic Interactions Between Spindle Assembly Checkpoint Proteins and B-type Cyclins in Saccharomyces Cerevisiae." Genetics 183.1, September: 51-61. (Books and Publications: Article (Peer-reviewed)) 2009

Ikui, A.E., V. Archambault, B.J. Drapkin, V. Campbell and F.R. Cross. "Cyclin and Cyclin-Dependent Kinase Substrate Requirements for Preventing Rereplication Reveal the Need for Concomitant Activation and Inhibition." Genetics 175.3, March: 1011-22. (Books and Publications: Article (Peer-reviewed)) 2007

Archambault, V., A.E. Ikui, B.J. Drapkin and F.R. Cross. "Disruption of Mechanisms that Prevent Rereplication Triggers a DNA Damage Response." Molecular Cell Biology 25.15, August: 6707-21. (Books and Publications: Article (Peer-reviewed)) 2005

Ikui, A.E., C.P. Yang, T. Matsumoto and S.B. Horwitz. "Low Concentrations of Taxol Cause Mitotic Delay Followed by Premature Dissociation of p55CDC from Mad2 and BubR1 and Abrogation of the Spindle Checkpoint, Leading to Aneuploidy." Cell Cycle 4.10, October: 1385-88. (Books and Publications: Article (Peer-reviewed)) 2005

Ikui, A.E., K. Furuya, M. Yanagida and T. Matsumoto. "Control of Localization of a Spindle Checkpoint Protein, Mad2, in Fission Yeast." Journal of Cell Science 115 (Part 8), Apr. 15: 1603-10. (Books and Publications: Article (Peer-reviewed)) 2002

Ikui, A.E., Y. Yao, P. Zhou and I.B. Weinstein. "Induction of Apoptosis by Sulindac Sulfide in HL60 Cells Is Enhanced by p21CiP1 or p27KiP1." Anticancer Research 21.4A, July-August: 2297-303. (Books and Publications: Article (Peer-reviewed)) 2001

Awards, Honors and Fellowships

NIH SC1 grant. $1,570,000; 2021-25. (Grants and Fellowships) 2021 (Grants and Fellowships) 2021

NIH SC1 grant. $1,426,000; 2017-21. (Grants and Fellowships) 2017

NIH SC3 grant. $471,000; 2013-17. (Grants and Fellowships) 2013

PSC-CUNY enhanced award. $11,000. (Grants and Fellowships) 2013

PSC-CUNY enhanced award. $12,000. (Grants and Fellowships) 2012

NIH SC2 grant. $471,000; 2010-13. (Grants and Fellowships) 2010

PSC-CUNY Award. $6,000. (Awards and Honors) 2010

PSC-CUNY Award. $6,000. (Grants and Fellowships) 2009

Charles Revson Postdoctoral Fellowship. (Grants and Fellowships) 2004

Conferences, Seminars and Symposiums

City College of New York (CUNY) (Conferences, Seminars and Symposiums: Invited Talk) 2019

Yeast Genetics Meeting at Stanford University (Conferences, Seminars and Symposiums: Contributed Talk) 2018

Cold Spring Harbor Laboratory Cell Cycle Meeting. (Conferences, Seminars and Symposiums: Contributed Talk) 2016

Cold Spring Harbor Laboratory Cell Biology of Yeast Meeting. (Conferences, Seminars and Symposiums: Contributed Talk) 2015

St. John's University (Conferences, Seminars and Symposiums: Invited Talk) 2015

Nagoya City University. Japan. (Conferences, Seminars and Symposiums: Invited Talk) 2014

Cold Spring Harbor Laboratory Cell Biology of Yeast Meeting. (Conferences, Seminars and Symposiums: Contributed Talk) 2013

Cold Spring Harbor Laboratory DNA Replication Meeting. (Conferences, Seminars and Symposiums: Contributed Talk) 2013

National Institute of Genetics. Japan. (Conferences, Seminars and Symposiums: Invited Talk) 2013

University of Tokyo. Japan. (Conferences, Seminars and Symposiums: Invited Talk) 2013

Cold Spring Harbor Laboratory Cell Cycle Meeting. (Conferences, Seminars and Symposiums: Contributed Talk) 2012

Osaka University. Osaka, Japan. (Conferences, Seminars and Symposiums: Invited Talk) 2012

Yeast Genetics Meeting. Princeton University. Princeton, N.J. (Conferences, Seminars and Symposiums: Contributed Talk) 2012

Cold Spring Harbor Laboratory DNA Replication Meeting. (Conferences, Seminars and Symposiums: Contributed Talk) 2011

Cold Spring Harbor Laboratory Yeast Cell Biology Meeting. (Conferences, Seminars and Symposiums: Contributed Talk) 2011

Hunter College (CUNY). (Conferences, Seminars and Symposiums: Invited Talk) 2011

SUNY Downstate Medical Center. Brooklyn, N.Y. (Conferences, Seminars and Symposiums: Invited Talk) 2011

International Cell Cycle and Development Meeting. Singapore. (Conferences, Seminars and Symposiums: Invited Talk) 2010

York College (CUNY). (Conferences, Seminars and Symposiums: Invited Talk) 2010

Albert Einstein College of Medicine. (Conferences, Seminars and Symposiums: Invited Talk) 2004

Professional Leadership

Session Chair at Mitosis and Meiosis Meeting in Roscoff, France (Professional Leadership: Organizational Leadership Position) 2019