Education:
Ph.D., Cornell University - 2001 (Genetics)
B.A., Hunter College (CUNY) - 1993 (Biological Sciences)
Areas of Expertise:
Barbara Studamire analyzes interactions between retroviral and host proteins using the tools of genetics, molecular biology and biochemistry. Her lab focuses primarily on the retroviral integrase protein and its interactions with host factors and chromatin.
Doctoral Rotation Projects:
As a graduate student, Studamire isolated and characterized mutations in the yeast mismatch repair genes MSH2 and MSH6. She has broad experience in protein purification, molecular biological methods, and cell culture techniques. A variety of exciting research projects are available for highly motivated graduate and undergraduate students in her lab at Brooklyn College. A strong background in chemistry and biology is preferred. Studamire's lab examines different host proteins for roles in viral integration and replication and is using gene expression analysis to assess the effects of these proteins. Among the methods used in the projects are cloning, protein knockdown and over-expression, microscopy, immunoassays and bioinformatics. The lab also uses interaction-trap assays to assess protein-protein interactions between virus and host.
Books and Publications
Samarrai, W., D.X. Liu, A.-M. White, B. Studamire, J. Edelstein, A. Srivastava, R.L. Widom and R. Rudner. "Differential Responses of Bacillus subtilis rRNA Promoters to Nutritional Stress." Journal of Bacteriology 193: 723-33. (Books and Publications: Peer Reviewed Article) 2011
Studamire, B. and S.P. Goff. "Interactions of Host Proteins With the Murine Leukemia Virus Integrase." Viruses 2: 1110-45. doi:10.3390/v2051110 (review). (Books and Publications: Peer Reviewed Article) 2010
Studamire, B. and S.P. Goff. "Host Proteins Interacting With the Moloney Murine Leukemia Virus Integrase: Multiple Transcriptional Regulators and Chromatin Binding Factors." Retrovirology 5: 48. (Books and Publications: Peer Reviewed Article) 2008
Sugawara, N., T. Goldfarb, B. Studamire, E. Alani and JE Haber. "Heteroduplex Rejection During Single-strand Annealing Requires Sgs1 helicase and Mismatch Repair Proteins Msh2 and Msh6 but Not Pms1." Proceedings of the National Academy of Science 101: 9315-20. (Books and Publications: Peer Reviewed Article) 2004
Kijas, AW, B. Studamire and E. Alani. "Msh2 Separation of Function Mutations Confer Defects in the Initiation Steps of Mismatch Repair." Journal of Molecular Biology 33: 123-38. (Books and Publications: Peer Reviewed Article) 2003
Studamire, B., G. Price, N. Sugawara, J. Haber and E. Alani. "Separation-of-function Mutations in Saccharomyces cerevisiae MSH2 That Confer Mismatch Repair Defects but Do Not Affect Nonhomologous-tail Removal During Recombination." Molecular and Cellular Biology 19: 7558-67. (Books and Publications: Peer Reviewed Article) 1999
Studamire, B., T. Quach and E. Alani. "Saccharomyces cerevisiae Msh2p and Msh6p ATPase Activities Are Both Required During Mismatch Repair." Molecular and Cellular Biology 18: 7590-01. (Books and Publications: Peer Reviewed Article) 1998
Awards, Honors and Fellowships
NIGMS Pilot Research Award, for "The Influence of Host Factors on Retroviral Integration Into Chromatin Templates." 2009-12. (Grants and Fellowships) 2009
PSC-CUNY Award, for "Host Factors Interacting With the Moloney Murine Leukemia Virus Integrase." (Grants and Fellowships) 2009
New Faculty Award, Brooklyn College. (Grants and Fellowships) 2008
Professional Leadership
Member, Biology Department Research and Administrative Space Allocation and Redesign Committee. (Professional Leadership: Committee Service) 2013
Member, Master of Science Program Advisory Committee, Biology Department. (Professional Leadership: Committee Service) 2013
Graduate deputy chair. Representative from Brooklyn College for the CUNY Ph.D. program in biology. (Professional Leadership: Organizational Leadership Position) 2012
Member, Biology Department Research and Administrative Space Allocation and Redesign Committee. (Professional Leadership: Committee Service) 2012
Member, Master of Science Program Advisory Committee, Biology Department. (Professional Leadership: Committee Service) 2012
Graduate deputy chair. Representative from Brooklyn College for the CUNY Ph.D. program in biology. (Professional Leadership: Organizational Leadership Position) 2011
Member, Biology Department Research and Administrative Space Allocation and Redesign Committee. (Professional Leadership: Committee Service) 2011
Member, Prokaryotic New Faculty Search Committee. (Professional Leadership: Committee Service) 2011
Graduate deputy chair, representative for Brooklyn College to the CUNY Graduate Center. (Professional Leadership: Organizational Leadership Position) 2010
Member, Biochemistry Ph.D. Program Admissions Committee. (Professional Leadership: Committee Service) 2010
Member, Biology Department Research and Administrative Space Allocation and Redesign Committee. (Professional Leadership: Committee Service) 2010
Graduate deputy chair. Representative from Brooklyn College for the CUNY Ph.D. program in biology. (Professional Leadership: Organizational Leadership Position) 2009
Member, Biology Department Research and Administrative Space Allocation and Redesign Committee. (Professional Leadership: Committee Service) 2009
Member, Biology Department Research and Administrative Space Allocation and Redesign Committee. (Professional Leadership: Committee Service) 2008
Community Activities
Liaison between the Cornell University Molecular Biology graduate program and the Brooklyn College MARC program office. This is part of an ongoing effort to recruit more students to Ph.D. in the Brooklyn College Biology Department. 2012
Liaison between the Cornell University Molecular Biology graduate program and the Brooklyn College MARC program office. This is part of an effort to recruit more students to Ph.D. programs in the Brooklyn College Biology Department. 2011
