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- Detailed Information
Xinyin Jiang
Associate Professor
Health and Nutrition Sciences
Location: 4110c Ingersoll Hall
Phone: 718.951.5000 x2738
Fax: 718.951.4670
Email:
Xinyin Jiang received both her doctoral degree in nutrition and her registered dietitian credential at Cornell University, Ithaca, NY in 2013. She studies nutrients involved in one carbon metabolism, such as choline, betaine, folate and vitamin B12, which regulate early development via multiple pathways. Her research group currently conducts mammalian cell culture, animal and human studies to assess the influence of choline intake during pregnancy on molecular and functional changes in the maternal-fetal dyad.
Education:
Ph.D., Cornell University (Ithaca, NY) - 2013 (Nutrition)
B.S., Fudan University (Shanghai, China) - 2008 (Biology)
Areas of Expertise:
Maternal and child nutrition, nutrition and disease, one carbon metabolism, choline, gestational diabetes, maternal obesity, epigenetics, fetal programming
Books and Publications
Jiang K, Zhang Z, Fullington LA, Huang TT, Kaliszewski C, Wei J, Zhao L, Huang S, Ellithorpe A, Wu S, Jiang X, Wang L. "Dietary Patterns and Obesity in Chinese Adults: A Systematic Review and Meta-Analysis". Nutrients. 2022; 14, 4911. (Books and Publications: Article (Peer-reviewed)) 2022
Korsmo H, Dave B, Trasino S, Saxena A, Liu J, Caviglia JM, Edwards K, Dembitzer M, Sheeraz S, Khaldi S, Jiang X. "Maternal choline supplementation and high-fat feeding interact to influence DNA methylation in offspring in a time-specific manner". Frontiers in Nutrition, 2022; 9,841787 (Books and Publications: Article (Peer-reviewed)) 2022
Greenberg J, Jiang X, Tinker L, Snetselaar L, Saquib N, Shadyab AH. "Consumption of eggs,
cholesterol, choline and betaine and diabetes risk in the Women's Health Initiative". American
Journal of Clinical Nutrition, 2021; 114(1): 368-377. (Books and Publications: Article (Peer-reviewed)) 2021
Kadam I, Neupane S, Wei J, Fullington LA, Li T, An R, Zhao L, Ellithorpe A, Jiang X, Wang L. "A
Systematic Review of Diet Quality Index and Obesity among Chinese Adults". Nutrients 2021; 13,
3555. (Books and Publications: Article (Peer-reviewed)) 2021
Korsmo H, Jiang X. "One carbon metabolism and early development: a diet-dependent destiny". Trends in Endocrinology and Metabolism. 2021;32(8):579-593. (Books and Publications: Article (Peer-reviewed)) 2021
Jack-Roberts C, Maples, P, Kalkan, B, Edwards, K, Gilboa, E, Djuraev, I, Zou, S, Hoepner, L, Fordjour
L, Lee WC, Kral, J, Dalloul, M, Jiang X. "Gestational diabetes status and dietary intake modify maternal
and cord blood allostatic load markers". BMJ Open Diabetes Research and Care. 2020; 8(1):
e001468. (Books and Publications: Article (Peer-reviewed)) 2020
Jiang X. "Diet and Hemostasis". In Book: Nutrition in Clinical Practice, 4th Edition, David Katz, Ming-
Chin Yeh, Joshua Levitt, Kofi D. Essel, Shivam Joshi, Rachel Summer, Claire Friedman, eds.:
Philadelphia, PA: Wolters Kluwer. (Books and Publications: Book Chapter) 2020
Korsmo HW, Edwards K, Dave B, Jack-Roberts C, Yu H, Saxena A, Salvador M, Dembitzer M,
Phagoora J, Jiang X. "Prenatal Choline Supplementation during High-Fat Feeding Improves Long Term Blood Glucose Control in Male Mouse Offspring". Nutrients. 2020; 12(1), 144 (Books and Publications: Article (Peer-reviewed)) 2020
Jack-Roberts C, Maples P, Dalloul M, Kral J, Hoepner L, Saxena A, Jiang X. "Hypothalamus-pituitary-adrenal axis biomarkers are associated with maternal gestational psychosocial stress and dietary choline", The American Society for Nutrition "Nutrition 2019" Conference, Baltimore, MD, 2019
(Books and Publications: Abstract) 2019
King J, Kwan ST, Bae S, Klatt K, Yan J, Malysheva O, Jiang X, Roberson M, Caudill M. "Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy". J Nutr Biochem. 2019; 72:108210
(Books and Publications: Article (Peer-reviewed)) 2019
King J, Kwan ST, Yan J, Jiang X, Fomin V, Levine S, Wei E, Roberson M, Caudill M. "Maternal choline supplementation modulates placental markers of inflammation, angiogenesis, and apoptosis in a mouse model of placental insufficiency". Nutrients. 2019;11(2). (Books and Publications: Article (Peer-reviewed)) 2019
Korsmo H, Jiang X, Caudill M. "Choline: Exploring the Growing Science on Its Benefits for Moms and Babies". Nutrients. 2019; 11(8), 1823. (Books and Publications: Article (Peer-reviewed)) 2019
Korsmo WH, Edwards K, Dave B, Jack-Roberts C, Jiang X. "Maternal Choline Supplementation During Gestational Diabetes Causes Long-Term Phenotypic Changes in Offspring", The American Society for Nutrition "Nutrition 2019" Conference, Baltimore, MD, 2019 (Books and Publications: Abstract) 2019
Jack-Roberts C, Dalloul M, Kral J, Haughton M, Jiang X. "Choline and Placental Macronutrient Metabolism in Gestational Diabetes-Complicated Pregnancies". The American Society for Nutrition "Nutrition 2018" Conference, Boston, MA, 2018 (Books and Publications: Abstract) 2018
Jiang X, Nanobashvili K, Jack-Roberts C, Jones N. "Maternal choline supplementation improves weight and blood glucose control in mouse progeny exposed to maternal high-fat feeding during gestation". FESEB SRC, Western Shore, Nova Scotia, Canada, 2018 (Books and Publications: Abstract) 2018
Joselit Y, Nanobashvili K, Jack-Roberts C, Greenwald E, Malysheva OV, Caudill MA, Saxena A, Jiang X.
"Maternal betaine supplementation affects fetal growth and lipid metabolism of high-fat fed mice in a temporal-specific manner". Nutr Diabetes. 2018;8(1):41.
(Books and Publications: Article (Peer-reviewed)) 2018
Joselit Y, Nanobashvili K, Jack-Roberts C, Greenwald E, Malysheva OV, Caudill MA, Saxena A, Jiang X. "The effect of maternal betaine supplementation on fetal growth and lipid metabolism of high-fat fed mice". The American Society for Nutrition "Nutrition 2018" Conference, Boston, MA, 2018 (Books and Publications: Abstract) 2018
Kwan STC, King JH, Grenier JK, Yan J, Jiang X, Roberson MS, Caudill MA. "Maternal Choline Supplementation during Normal Murine Pregnancy Alters the Placental Epigenome: Results of an Exploratory Study." Nutrients. 2018;10(4). pii: E417. (Books and Publications: Article (Peer-reviewed)) 2018
Nanobashvili K, Jack-Roberts C, Bretter R, Jones N, Axen K, Saxena A, Blain K, and Jiang X, "Maternal Choline and Betaine Supplementation Modifies the Placental Response to Hyperglycemia in Mice and Human Trophoblasts". Nutrients. 2018;10(10). (Books and Publications: Article (Peer-reviewed)) 2018
Nanobashvili K, Bretter R, Jack-Roberts C, Blain K, Dave B, Jones N, Joselit Y, Saxena A, Axen K, Jiang X. "Influence of Choline Derivatives on Placental Macronutrient Uptake and Transport", The American Society for Nutrition "Nutrition 2018" Conference, Boston, MA, 2018 (Books and Publications: Abstract) 2018
Jack-Roberts C, Joselit Y, Nanobashvili K, Bretter R, Malysheva OV, Caudill MA, Saxena A, Axen K, Gomaa A, Jiang X. "Choline Supplementation Normalizes Fetal Adiposity and Reduces Lipogenic Gene Expression in a Mouse Model of Maternal Obesity". Nutrients. 2017;9(8). (Books and Publications: Article (Peer-reviewed)) 2017
Jiang X, Nanobashvili K, Jack-Roberts C, Bretter R, Saxena A. "Effects of choline supplementation on placental morphology and gene expression in mouse and trophoblast models of hyperglycemia", Placenta 57:265. International Federation of Placenta Associations: IFPA 2017 Conference, Manchester, UK, 2017 (Books and Publications: Abstract) 2017
Joselit Y, Jack-Roberts C, Axen K, Jiang X, "Choline and betaine supplementation altered fetal docosahexaenoic acid metabolizing gene expression in a mouse model of gestational diabetes", FASEB Experimental Biology, Chicago, IL, 2017 (Books and Publications: Abstract) 2017
King JH, Kwan STC, Yan J, Klatt KC, Jiang X, Roberson MS, Caudill MA. "Maternal Choline Supplementation Alters Fetal Growth Patterns in a Mouse Model of Placental Insufficiency". Nutrients. 2017;9(7). (Books and Publications: Article (Peer-reviewed)) 2017
Kwan STC, King JH, Yan J, Jiang X, Wei E, Fomin VG, Roberson MS, Caudill MA. "Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation, apoptosis and vascularization in a fetal sex-dependent manner". Placenta. 2017;53:57-65. (Books and Publications: Article (Peer-reviewed)) 2017
Kwan STC, King JH, Yan J, Wang Z, Jiang X, Hutzler JS, Klein HR, Brenna JT, Roberson MS, Caudill MA. "Maternal Choline Supplementation Modulates Placental Nutrient Transport and Metabolism in Late Gestation of Mouse Pregnancy". J Nutr. 2017;147(11):2083-2092. (Books and Publications: Article (Peer-reviewed)) 2017
Nam J, Greenwald E, Jack-Roberts C, Ajeeb TT, Malysheva OV, Caudill MA, Axen K, Saxena A, Semernina E, Nanobashvili K, Jiang X. "Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity". J Nutr Biochem. 2017;49:80-88. (Books and Publications: Article (Peer-reviewed)) 2017
Jiang X, Greenwald E, Jack-Roberts C. "Differential effects of choline and glucose on macronutrient metabolic gene expression in HepG2 and BeWo cells", FASEB Experimental Biology, San Diego, CA, 2016 (Books and Publications: Abstract) 2016
Jiang X, Greenwald E, Nam J, Ajeeb T, "Betaine supplementation reduces placental glucose and fatty acid transport in a mouse model of maternal high fat feeding", American Diabetes Association 76th Scientific Sessions, New Orleans, LA, 2016 (Books and Publications: Abstract) 2016
Jiang, X, Greenwald, E, Jack-Roberts, C. "Effects of Choline on DNA Methylation and Macronutrient Metabolic Gene Expression in In Vitro Models of Hyperglycemia". Nutr Metab Insights. 2016;9:11-7. (Books and Publications: Article (Peer-reviewed)) 2016
Jiang, X., "Nutrition in early life, epigenetics, and health". In "Epigenetics, the Environment, and Children's Health" (Hollar, D, ed), 2016; Springer, pp135-158
(Books and Publications: Book Chapter) 2016
Park H, Brannon PM, West AA, Yan J, Jiang X, Perry CA, Malysheva O, Mehta S, Caudill MA. "Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus". Bone. 2017;95:183-191. (Books and Publications: Article (Peer-reviewed)) 2016
Park H, Brannon PM, West AA, Yan J, Jiang X, Perry CA, Malysheva OV, Mehta S, Caudill MA. "Vitamin D Metabolism Varies among Women in Different Reproductive States Consuming the Same Intakes of Vitamin D and Related Nutrients". J Nutr. 2016;146(8):1537-45. (Books and Publications: Article (Peer-reviewed)) 2016
Bae, S, West, AA, Yan, J, Jiang, X, Perry, CA, Malysheva, O, Stabler, SP, Allen, RH, Caudill, MA. "Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes", J Nutr. 2015;145(7):1507-14. (Books and Publications: Article (Peer-reviewed)) 2015
Davenport, C, Yan, J, Taesuwan, S, Shields, K, West, AA, Jiang, X, Perry, CA, Malysheva, OV, Stabler, SP, Allen, RH, Caudill, MA. "Choline intakes exceeding recommendations during human lactation improve breastmilk choline content by increasing PEMT pathway metabolites." J Nutr Biochem, 2015, 26 (9): 902-11 (Books and Publications: Article (Peer-reviewed)) 2015
Jiang, X. "Betaine, A Potent Mediator of Metabolic Programming?" Journal of Nutritional Health & Food Engineering 2.1: 00041. (Books and Publications: Article (Other)) 2015
Nam J, Jiang X. "Choline and betaine supplementation affects biomarkers in mice with gestational diabetes". FASEB J, 2015; 29 (1) supplement 754.2, FASEB Experimental Biology, Boston, MA, 2015 (Books and Publications: Abstract) 2015
Jiang, X., A.A. West and M.A. Caudill. "Maternal Choline Supplementation: A Nutritional Approach for Improving Offspring Health." Trends in Endocrinology and Metabolism, 2014, 25 (5), 263-273 (Books and Publications: Forthcoming Publications) 2014
Jiang, X., S. Jones, B. Andrew, A. Ganti, O.V. Malysheva, N. Giallourou, P.M. Brannon, M.S. Roberson and M.A. Caudill. "Choline Inadequacy Impairs Trophoblast Function and Vascularization in Cultured Human Placental Trophoblasts." Journal of Cellular Physiology, 2014; 228 (8):1016-1027 (Books and Publications: Forthcoming Publications) 2014
Perry, C.A., A.A. West, A. Gayle, L.K. Lucas, J. Yan, X. Jiang, O. Malysheva and M.A. Caudill. "Pregnancy and Lactation Alter Biomarkers of Biotin Metabolism in Women Consuming a Controlled Diet." Journal of Nutrition 144.12: 1977-84. (Books and Publications: Article (Peer-reviewed)) 2014
Jiang, X., H.Y. Bar, J. Yan, S. Jones, P.M. Brannon, A.A. West, C.A. Perry, O.M. Malysheva, E. Pressman, S. Devapatla, F.M. Vermeylen, T.M. Wells and M.A. Caudill. "A Higher Maternal Choline Intake Decreases the Anti-angiogenic Factor fms-like Tyrosine Kinase-1 (sFLT1) in Both the Placenta and Maternal Circulation. FASEB Journal 27.3: 1245-53. (Books and Publications: Article (Peer-reviewed)) 2013
Jiang, X., J. Yan and M.A. Caudill. "Choline." Handbook of Vitamins 5th ed. Eds. J. Zempleni, J.W. Suttie and J.F. Gregory III. Taylor & Francis LLC. 492-508. (Books and Publications: Book Chapter) 2013
Mikael, L.G., J. Pancer, X. Jiang, Q. Wu, M. Caudill and R. Rozen. "Low Dietary Folate and Methylenetetrahydrofolate Reductase Deficiency May Lead to Pregnancy Complications Through Modulation of ApoAI and IFN-γ in Spleen and Placenta, and Through Reduction of Methylation Potential." Molecular Nutrition & Food Research 57.4: 661-70. (Books and Publications: Article (Peer-reviewed)) 2013
West, A.A., J. Yan, X. Jiang, C.A. Perry, S.M. Innis and M.A. Caudill. "Choline Intake Influences Phosphatidylcholine DHA Enrichment in Nonpregnant Women But Not in Pregnant Women in the Third Trimester." American Journal of Clinical Nutrition 97.4: 718-27. (Books and Publications: Article (Peer-reviewed)) 2013
Yan, J., X. Jiang, A.A. West, C.A. Perry, O.V. Malysheva, J.T. Brenna, S.P. Stabler, R.H. Allen, J.F. Gregory III and M.A. Caudill. "Pregnancy Alters Choline Dynamics: Results of a Randomized Trial Using Stable Isotope Methodology in Pregnant and Nonpregnant Women." American Journal of Clinical Nutrition 98.6: 1459-67. (Books and Publications: Article (Peer-reviewed)) 2013
Jiang, X., H.Y. Bar, J. Yan, A.A. West, C.A. Perry, O.M. Malysheva, E. Pressman, S. Devapatla, F.M. Vermeylen, T.M. Wells and M.A. Caudill. "Pregnancy Induces Transcriptional Activation of the Peripheral Innate Immune System and Increases Oxidative DNA Damage Among Healthy Third Trimester Pregnant Women." PLoS ONE 7.11: e46736. (Books and Publications: Article (Peer-reviewed)) 2012
Jiang, X., J. Yan, A.A. West, C.A. Perry, O.V. Malysheva, S. Devapatla, E. Pressman, F. Vermeylen and M.A. Caudill. "Maternal Choline Intake Alters the Epigenetic State of Fetal Cortisol-regulating Genes in Humans." FASEB Journal 26.8: 3563-74. (Books and Publications: Article (Peer-reviewed)) 2012
West, A.A., J. Yan, C.A. Perry, X. Jiang, O.V. Malysheva and M.A. Caudill. "Folate-status Response to a Controlled Folate Intake in Nonpregnant, Pregnant, and Lactating Women." American Journal of Clinical Nutrition 96.4: 789-800. (Books and Publications: Article (Peer-reviewed)) 2012
Yan, J., X. Jiang, A.A. West, C.A. Perry, O.V. Malysheva, S. Devapatla, E. Pressman, F. Vermeylen, S.P. Stabler, R.H. Allen, et al. "Maternal Choline Intake Modulates Maternal and Fetal Biomarkers of Choline Metabolism in Humans." American Journal of Clinical Nutrition 95: 1060-71. (Books and Publications: Article (Peer-reviewed)) 2012
Chew, T.W., X.Y. Jiang, J. Yan, W. Wang, A.L. Lusa, B.J. Carrier, A.A. West, O.V. Malysheva, J.T. Brenna, J.F. Gregory, et al. "Folate Intake, Mthfr Genotype, and Sex Modulate Choline Metabolism in Mice." Journal of Nutrition 141: 1475-81. (Books and Publications: Article (Peer-reviewed)) 2011
Awards, Honors and Fellowships
Research Grant, PI, "Choline as an epigenetic reliever of nonalcoholic steatohepatitis initiated by maternal obesity", CUNY ASRC-Seed grant (Grants and Fellowships) 2021
Research grant, PI, "Lifelong choline supplementation to reverse nonalcoholic steatohepatitis". PSC-CUNY Enhanced Award (Grants and Fellowships) 2021
The Stewart Travel Awards for Assistant Professor, The CUNY Academy for the Humanities and Sciences (Awards and Honors) 2019
Research Grant, Co-investigator, "Effects of choline supplementation on fetal growth in gestational diabetes mellitus", the Maimonides Research and Development Foundation (MRDF) Spring/Summer 2019 Grant (PI: Fisher N) (Grants and Fellowships) 2019
Research Grant, PI, "Effects of maternal choline supplementation on liver metabolism and severity of alcoholic liver disease in mouse offspring exposed to alcohol in utero", PSC-CUNY Enhance Award (Grants and Fellowships) 2019
Research Grant, PI, "Long-term effects of maternal choline supplementation on lipid metabolism of offspring exposed to maternal high-fat feeding", Support of Competitive Research (SC3), National Institute of General Medical Sciences (NIGMS), NIH (Grants and Fellowships) 2019
Top Reviewers for Advances in Nutrition (AN) in 2018, Advances in Nutrition, an International Review Journal (Awards and Honors) 2019
Research Grant, PI, "Maternal egg consumption during pregnancy and cognitive development in offspring", Egg Nutrition Center, American Egg Board (Grants and Fellowships) 2018
Outstanding Abstract Award (First Prize), Belt and Road Initiative Global Health International Congress & 2018 Global Health Forum, Xi'an, China, 2018
(Awards and Honors) 2018
Interdisciplinary Research Grant (IRG), PI, "The role of choline in reducing perinatal stress and improving birth outcomes of gestational diabetes in a high-risk urban population", CUNY (Grants and Fellowships) 2017
Enhance Research Award, PI, "Influence of betaine on placental macronutrient transport and gestational diabetes-induced macrosomia", PSC-CUNY (Grants and Fellowships) 2016
Nutrition Research Award, PI, "Prenatal betaine supplementation as a treatment for macrosomia in a mouse model of gestational diabetes mellitus", The Sackler Institute for Nutrition Sciences, New York Academy of Sciences (Grants and Fellowships) 2016
Travel Award, FESEB "Folic Acid, Vitamin B12, and One-Carbon Metabolism" Science Research Conference (Awards and Honors) 2016
NIH SCORE2, for "Effects of choline on fetal growth and lipid accretion in gestational diabetes". Role: PI (Grants and Fellowships) 2015
PSC-CUNY Traditional A, for "Investigate the Dose Response Effects of Methyl Nutrients on the Epigenetic Regulation of Placental Cells." role: PI (Grants and Fellowships) 2014
American Society for Nutrition predoctoral fellowship. (Grants and Fellowships) 2010
Nell Mondy Fellowship, Sigma Delta Epsilon/Graduate Women in Science. (Grants and Fellowships) 2010
Conferences, Seminars and Symposiums
Department of Public Health Research Seminar at Capital Medical University, Beijing, China, 11/23/2018. "Choline and the Developmental Origins of Health and Disease" (Conferences, Seminars and Symposiums: Invited Talk) 2018
Oral presentation, the Young Scholar Forum of the Belt and Road Initiative Global Health International Congress & 2018 Global Health Forum for the University Alliance of the Silk Road, Xi'an, China, 11/25/18. "The Influence of Prenatal Choline Exposure on the Growth and Metabolic Functioning of Offspring Affected by Gestational Diabetes Mellitus: Preliminary Results from Mouse and Human Studies"
(Conferences, Seminars and Symposiums: Conference Presentation) 2018
2016 FASEB "Folic Acid, Vitamin B12, and One-Carbon Metabolism" Science Research Conference, Steamboat Springs, CO, 08/10/2016, "Choline supplementation altered placental macronutrient metabolism in a mouse model of maternal high-fat feeding"
(Conferences, Seminars and Symposiums: Conference Presentation) 2016
Cell Biology Research Seminar at SUNY Downstate Medical Center, Brooklyn, NY, 06/01/2016
"Choline and prenatal programming"
(Conferences, Seminars and Symposiums: Invited Talk) 2016
Department of Public Health Research Seminar at Sun Yat-Sen University, Guangzhou, China, 1/21/2016,
"Choline and perinatal health"
(Conferences, Seminars and Symposiums: Invited Talk) 2016
2015 American Chemistry Society's Northeast Regional Meeting, Ithaca, NY, 6/11/2015,
"Choline supplementation during pregnancy and perinatal health"
(Conferences, Seminars and Symposiums: Conference Presentation) 2015
