Education:
Ph.D., Oxford University, United Kingdom - 1989 (Molecular Biology)
Areas of Expertise:
The long-term goals of He's lab are elucidating how neurons in the nervous system are formed and organized into functional circuits during animal development. They utilize a combination of methods, including molecular and cell biology, genetics, advanced microscopic imaging and transgenic techniques. Together, these approaches offer a promising path to advancing our understanding about the structure and function of the central nervous system.
Doctoral Rotation Projects:
He is interested in the development of the brain, and the lab uses multiple approaches ranging from molecular cell biology to genetics to developmental biology. Rotating students have the opportunity to conduct research using some of the most advanced techniques available, including recombinant DNA manipulation, synthesizing genetic background, analyzing gene functions, live animal tissue imaging and advanced confocal microscopy. Potential rotation projects include: (1) constructing plasmids for expression and mutagenesis; (2) analyzing mutated animals for functional defects; (3) characterizing neural connectivity and lineage in the brain; and (4) building cell type specific makers using fluorescent proteins such as GFP, RFP and others. These projects will offer unique opportunities to experience firsthand the power of various techniques as well as to enrich individual's knowledge and judgment in one of the most active research fields, developmental biology.
Books and Publications
"Functional Analysis of Actin-Binding Proteins in the Central Nervous System in Drosophila." Methods in Molecular Biology 186: 367-73. (Books and Publications: Chapter) 2009
Garcia, M.C., M. Abbasi, S. Singh and Q. He. "Role of Drosophila Gene Dunc-115 in Nervous System." Invertebrate Neuroscience 7: 119-28. (Books and Publications: Peer Reviewed Article) 2007
Dearborn, R., Q. He, S. Kunes and Y. Dai. "Eph Receptor Tyrosine Kinase-Mediated Topographic Map Formation in the Drosophila Visual System." Journal of Neuroscience 22: 1338-49. (Books and Publications: Peer Reviewed Article) 2002
"A Functional Analysis of the Involvement of Cytoskeleton Proteins in Drosophila Visual System." Methods in Molecular Biology 161: 279-83. (Books and Publications: Chapter) 2000
Jain*, M., Q. He*, et al. "Role of CD44 in the Reaction of Vascular Smooth Muscle Cells to Arterial Wall Injury." Journal Clinical Investigation 97: 596-603. (*These authors contributed equally.) (Books and Publications: Peer Reviewed Article) 1996
Shi, C., W. Lee, Q. He, D. Zhang, D.L. Fletcher Jr., J.B. Newell and E. Haber. "Immunologic Basis of Transplant-Associated Arteriosclerosis." Proceedings of the National Academy of Sciences USA 93: 4051-56. (Books and Publications: Peer Reviewed Article) 1996
Zheng, Z., S. Katoh, Q. He, K. Oritani, K. Miyake, J. Lesley, R. Hyman, A. Hamik, R.M.E. Parkhouse, A.G. Farr and P.W. Kincade. "Monoclonal Antibodies to CD44 and Their Influence on Hyaluronan Recognition." Journal of Cell Biology 130: 485-95. (Books and Publications: Peer Reviewed Article) 1995
Kincade, P.W., Q. He, K. Ishihara, K. Miyake, J. Lesley and R. Hyman. "CD44 and Other Cell Interaction Molecules Contributing to B Lymphopoiesis." Current Topics in Microbiology Immunology 184: 215-22. (Books and Publications: Peer Reviewed Article) 1993
He, Q., J. Lesley, R. Hyman, K. Ishihara and P.W. Kincade. "Molecular Isoforms of Murine CD44 and Evidence That the Membrane Proximal Domain Is Not Critical for Hyaluronate Recognition." Journal of Cell Biology 119: 1711-19. (Books and Publications: Peer Reviewed Article) 1992
Lesley, J., Q. He, K. Miyake, A. Hamann, R. Hyman and P.W. Kincade. "Requirements for Hyaluronic Acid Binding by CD44. A Role for the Cytoplasmic Domain and Activation by Antigen." Journal of Experimental Medicine 175: 257-66. (Books and Publications: Peer Reviewed Article) 1992
Beyers, A.D., A.N. Barclay, D.A. Law, Q. He and A.F. Williams. "Activation of T Lymphocytes via Monoclonal Antibodies Against Rat Cell Surface Antigens With Particular Reference to CD2 Antigen." Immunology Review 111: 60-77. (Books and Publications: Peer Reviewed Article) 1989
Williams, A.F., S.J. Davis, Q. He and A.N. Barclay. "Structure Diversity in Domains of the Immunoglobulin Superfamily." Cold Spring Harbor Symposia on Quantitative Biology 54: 637-47. (Books and Publications: Peer Reviewed Article) 1989
He, Q., A.D. Beyers, A.N. Barclay and A.F. Williams. "A Role in Transmembrane Signaling for the Cytoplasmic Domain of the CD2 T Lymphocyte Surface Antigen." Cell 54: 979-84. (Books and Publications: Peer Reviewed Article) 1988
He, Q. and F. Hwang. "Interaction Between Anisodamine and Sphingomyelin Liposomes: A Fluorescence and Spin Label Study." Acta Biophysica Sinica 12: 14-19. (Books and Publications: Peer Reviewed Article) 1986
Awards, Honors and Fellowships
PSC-CUNY Grant, for "Characterization of Drosophila Axonal Guidance Genes." July 2006-June 2011. (Grants and Fellowships) 2010
National Eye Institute of the NIH Grant #1R15EY12935-01, for "Genes for Axon Guidance in Drosophila Visual System." Sept. 1, 2000-Aug. 31, 2005. (Grants and Fellowships) 2005
Individual National Research Service Award, National Institutes of Health, 1995-97. (Grants and Fellowships) 1997
Travel Fellowship, K.C. Wong Education Foundation, Hong Kong. (Grants and Fellowships) 1997
ORS Awards, Oxford University, United Kingdom, 1987-89. (Awards and Honors) 1989
Predoctoral Fellowship, Chinese Academy of Sciences, 1986-89. (Grants and Fellowships) 1989
Conferences, Seminars and Symposiums
"Expression and Function of Dek in Drosophila Visual System." 39th Annual Drosophila Research Conference. United States. (Conferences, Seminars and Symposiums: Invited Talk) 1998
"Eph Kinases and Axon Projection in the Visual System." International Symposium on Biomembrane Research. Chinese Academy of Sciences. Beijing. (Conferences, Seminars and Symposiums: Invited Talk) 1997
