Ryan Murelli

Assistant Professor
Chemistry

Location: 437 Ingersoll Hall Extension
Phone: 718.951.5000 x2821
Fax: 718.951.4607
Email: Ryan Murelli's Web site

Ryan Murelli joined the Brooklyn College faculty in September 2010. He teaches organic chemistry in addition to conducting research at the college, and holds a joint appointment with the CUNY Graduate Center. His research interests are broad but are based around synthetic organic chemistry. He worked on total synthesis and synthetic methods development while earning his Ph.D. Following the completion of his thesis work, he began postdoctoral research at Yale University, where he worked on several projects spanning bacteriology, immunology and cancer research. His research at Brooklyn College is aimed at developing new synthetic methods and employing them toward the study and development of biologically active small molecules.

Show Scholarly Activities and Professional Accomplishments

Education:

Postdoctoral Training, Yale University - 2010 (Chemical Biology)

Ph.D., Boston College - 2007 (Organic Chemistry)

B.A., Hamilton College - 2002 (Chemistry)

Areas of Expertise:

Ryan Murelli's lab is interested in developing and using the tools of chemistry and biology to meet current challenges in medicine. A major driving force behind the lab's work is the development of new synthetic methods that enable rapid access to known but underexplored small molecules. These routes are then applied to studying and understanding the target's function, and developing improved analogs that could serve as therapeutics.

Books and Publications

D'Erasmo, M. P.; Masaoka, T.; Wilson, J. A.; Hunte, E. M. Jr.; Beutler, J. A.; Le Grice, S. F. J.; Murelli, R. P. 'Traceless Solid-Phase α-Hydroxtropolone Synthesis' Medicinal Chemistry Communication, Accepted. (Books and Publications: Peer Reviewed Article) 2016

D'Erasmo, M. P.; Meck, C.; Lewis, C. A.; Murelli, R. P. "Discovery and Development of a 3-Component Oxidopyrylium [5+2] Cycloaddition Reaction" Journal of Organic Chemistry, 81, 3744-51. (Books and Publications: Peer Reviewed Article) 2016

Ireland, P. J.; Tavis, J. E.; D'Erasmo, M. P.; Hirsch, D. R.; Murelli, R. P.; Cadiz, M. M.; Patel, B. S.; Gupta, A. K.; Edwards, T. C.; Korom, M.; Moran, E. A.; Morrison, L. A. "Synthetic α-hydroxytropolones inhibit replication of wild-type and acyclovir-resistant herpes simplex viruses" Antimicrobial Agents Chemotherapeutics, 60, 2140-9. (Books and Publications: Peer Reviewed Article) 2016

Masaoka, T.; Zhao, H.; Hirsch, D. R.; D'Erasmo, M. P.; Meck, C.; Varnado, B.; Gupta, A.; Meyers, M. J.; Baines, J. D.; Beutler, J. A.; Murelli, R. P.; Tang,L.; Le Grice, S. F. J. "Characterization the C-terminal nuclease domain of herpes simplex virus pUL15 as a target of nucleotidyltransferase inhibitors." Biochemistry, 55, 809-19. (Books and Publications: Peer Reviewed Article) 2016

Murelli, R. P.; D'Erasmo, M. P.; Hirsch, D. R.; Meck, C.; Masaoka, T.; Wilson, J. A.; Zhang, B.; Pal, R. K.; Gallicchio, E.; Beutler, J. A.; Le Grice, S. F. J. 'Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity' Medicinial Chemistry Communication, Accepted. (Books and Publications: Peer Reviewed Article) 2016

Lu, G., E. Lomonosova, X. Cheng, E.A. Moran, M.J. Meyers, S.F.J. Le Grice, C.J. Thomas, J.-K. Jiang, C. Meck, D.R. Hirsch, M.P. D'Erasemo, D.M. Suyabatmaz, R.P. Murelli and J.E. Tavis. "Hydroxylated tropolones inhibit hepatitis B virus replication by blocking the viral ribonuclease H activity." Antimicrobial Agents Chemotherapy 59: 1070-79. (Books and Publications: Peer Reviewed Article) 2015

Zhao, H.; Lin, Z.; Lynn, A. Y.; Varnado, B.; Beutler, J. A.; Murelli, R. P.; Le Grice, S. F. J.; Tang, L. "Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism" Nucleic Acids Res., 43, 11003-16. (Books and Publications: Peer Reviewed Article) 2015

D'Erasmo, M.P., W.B. Smith, A. Munoz, P. Mohandas, A.S. Au, J.J. Marineau, L.E.N. Quadri, J.E. Bradner and R.P. Murelli. "7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-e-2-ones: Readily Accessible and Highly Potent Anticancer Compounds." Bioorganic and Medicinal Chemistry Letters 24: 4035-38. (Books and Publications: Peer Reviewed Article) 2014

Hirsch, D.R., G.C. Cox, M.P. D'Erasmo, T. Shakya, C. Meck, N. Mohd, G.D. Wright and R.P. Murelli. "Inhibition of ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones." Bioorganic and Medicinal Chemistry Letters 24: 4943-47. (Books and Publications: Peer Reviewed Article) 2014

Meck, C., M.P. D' Erasmo, D.R. Hirsch and R.P. Murelli. "The Biology and Synthesis of α-hydroxytropolones." Medicinal Chemistry Communications 5: 842-52. (Books and Publications: Peer Reviewed Article) 2014

Williams, Y.D., C. Meck, N. Mohd and R.P. Murelli "Triflic Acid Mediated Rearrangements of 3-methoxy-8-oxabicyclo[3.2.1]octa-3,6-dien-2-ones: Synthesis of Methoxytropolones and Furans." Journal of Organic Chemistry 78: 11707-13. (Books and Publications: Peer Reviewed Article) 2013

Meck, C., N. Mohd and R.P. Murelli. "An oxidopyrylium cyclization/ring-opening route to polysubstituted alpha‑hydroxytropolones." Organic Letters 14: 5988-91. (Books and Publications: Peer Reviewed Article) 2012

Munoz, A. and R.P. Murelli. "Acid-mediated coupling of gamma-hydroxybutenolides and aldehydes: Synthesis of a new class of spirocyclic ketal-lactones." Tetrahedron Letters 53: 6779-81. (Books and Publications: Peer Reviewed Article) 2012

Nelson, J.W., A.G. Chamessian, P.J. McEnany, R.P. Murelli, B.I. Kazmiercak and D.A. Spiegel. "A Biosynthetic Strategy for Re-engineering the Staphylococcus Aureus Cell Wall With Non-native Small Molecules." ACS Chemical Biology 5: 1147-55. (Books and Publications: Peer Reviewed Article) 2010

Zhang, A.X., R.P. Murelli, C. Barinka, J. Michel, A. Cocleaza, W.L. Jorgensen, J. Lubkowski and D.A. Spiegel. "A Remote Arene Binding Site of Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules." Journal of the American Chemical Society 132: 12711-16. (Books and Publications: Peer Reviewed Article) 2010

Murelli, R.P., A.X. Zhang, J. Michel, W.L. Jorgensen and D.A. Spiegel. "Chemical Control Over Immune Recognition: A Class of Antibody-Recruiting Small Molecules (ARMs) That Target Prostate Cancer." Journal of the American Chemical Society 131: 17090-92. (Books and Publications: Peer Reviewed Article) 2009

Stern, E., S.M. Jay, S.L. Demento, R.P. Murelli, M.A. Reed, T. Malinski, D.A. Spiegel, D.J. Mooney and T.M. Fahmy. "Spatiotemporal Control Over Molecular Delivery and Cellular Encapsulation From Electropolymerized Micro and Nanopatterned Surfaces." Advanced Functional Materials 19: 2888-95. (Books and Publications: Peer Reviewed Article) 2009

Murelli, R.P., S. Catalán, M.P. Gannon and M.L. Snapper. "Ruthenium-Catalyzed Enyne Cross-Metathesis-Cyclopropanation: Three Component Access to Vinyl Cyclopropanes." Tetrahedron Letters 49: 5714-17. (Books and Publications: Peer Reviewed Article) 2008

Murelli, R.P. and M.L. Snapper. "Ruthenium-Catalyzed Tandem Cross-Metathesis/Wittig Olefination: Generation of Conjugated Dienoic Esters From Terminal Olefins." Organic Letters 9: 1749-52. (Books and Publications: Peer Reviewed Article) 2007

Murelli, R.P., A.K. Cheung and M.L. Snapper. "Conformationally Restricted (+)-Cacospongionolide B Analogues: Influence on Secretory Phospholipase A2 Inhibition." Journal of Organic Chemistry 72: 1545-52. (Books and Publications: Peer Reviewed Article) 2007

Cheung, A.K., R. Murelli and M.L. Snapper. "Total Syntheses of (+)- and (-)-Cacospongionolide B, Cacospongionolide E, and Related Analogues. Preliminary Study of Structural Features Required for Phospholipase A2 Inhibition." Journal of Organic Chemistry 69: 5712-19. (Books and Publications: Peer Reviewed Article) 2004

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