Education:
Ph.D., Syracuse University - 1987 (Physical Chemistry)
Areas of Expertise:
Dowd investigates the role of the protein osteocalcin in bone mineral properties during lead toxicity and low Mg2+ diets. She also investigates the molecular mechanism of how gap junctions between cells function and how they are altered in deafness and disease.
Doctoral Rotation Projects:
Research focuses on investigating the role of the protein osteocalcin in bone during lead toxicity and/or low Mg2+ diets. Mineral and matrix properties are examined in wild-type and osteocalcin knock-out mice using Fourier Transform Infrared Imaging and Micro-computed tomography.
Books and Publications
Kalmatsky, B.D., Y. Batir, T.A. Bargiello and T.L. Dowd. "Structural Studies of N-terminal Mutants of Connexin 32 using (1)H NMR Spectroscopy." Archives of Biochemistry and Biophysics 526.1: 1-8.
(Books and Publications: Peer Reviewed Article) 2012
Morrill, G.A., T.L. Dowd, A.B. Kostellow and R.K. Gupta. "Progesterone-induced Changes in the Phosphoryl Potential During the Meiotic Divisions in Amphibian Oocytes: Role of Na/K-ATPase." BMC Developmental Biology 11: 67, Nov. 6. (Books and Publications: Peer Reviewed Article) 2011
Monir, A.U., C.M. Gundberg, S.E. Yagerman, M.C.H. van der Meulen, W.C. Budell, A.L. Boskey and T.L. Dowd. "The Effect of Lead on Bone Mineral Properties From Female Adult C57/BL6 Mice." Bone 47: 994-99. (Books and Publications: Peer Reviewed Article) 2010
Kalmatsky, B., S. Bhagan, Qingxiu Tang, T. Bargiello and T.L. Dowd. "Structural Studies of the N-terminus of Connexin 32 Using 1H NMR spectroscopy." Archives of Biochemistry and Biophysics 490: 9-16. (Books and Publications: Peer Reviewed Article) 2009
Tang, Qingxiu, Terry L. Dowd, Vytas K. Verselis and Thaddeus A. Bargiello. "Conformational Changes in a Pore Forming Region Underlie Voltage Dependent Loop-Gating for an Unapposed Connexin Hemichannel." Journal of General Physiology 133: 555-70. (Books and Publications: Peer Reviewed Article) 2009
Dowd, T.L., L. Li and C.M. Gundberg. "The 1H NMR Structure of Bovine Pb2+- Osteocalcin and Implications for Pb2+ Toxicity." Biochim. Biophys. Acta, Proteins and Proteomics 1784: 1534-15. (Books and Publications: Peer Reviewed Article) 2008
Awards, Honors and Fellowships
NIH 1RO1-GM098584-01A1, for "Structure-function Relation of Connexin Disease Mutations." Principal investigator. Sept. 1, 2012 - Aug. 31, 2016; $109,468 per year. In this grant I investigate structural alterations in the N-termini of Connexin gap junction molecules in diseases such as deafness, fatal skin disease and neuropathy. I use NMR spectroscopy to produce structural data of these molecules, which are then analyzed with functional data showing alterations in gap junctions observed in these diseases. The structural and functional data may provide insight into the etiology of these diseases as well as molecular mechanistic information on gap junction assembly and gating. (Grants and Fellowships) 2012
NIH GM46889, for "Structure-Function Studies of Gap Junctions" Terry Dowd, principal investigator, subcontract. $118,000 total direct costs, April 1, 2006-March 31, 2010. (Grants and Fellowships) 2006
NIH/NIEHS 2 R01 ES009032-06A2, for "The Effect of Pb2+ Toxicity at the Molecular Level." Principal investigator. $650,000 total direct costs; Dec. 1, 2004-Nov. 30, 2011. (Grants and Fellowships) 2004
Conferences, Seminars and Symposiums
Ul Monir, A., S.E. Yagerman, M.C.H. van der Meulen, C.M. Gundberg, A.L. Boskey and T.L. Dowd. "The Effect of Lead on Bone Mineral Properties from Female Adult C57/BL6 Mice." American Society for Bone and Mineral Research. Montreal 23: S410, M146. (Conferences, Seminars and Symposiums: Conference Presentation) 2008
Li, L., C.M. Gundberg and T.L. Dowd. "The Three-Dimensional 1H NMR Structure of Bovine Lead Ion-Bound Osteocalcin and Implications for Lead Toxicity." American Society for Bone and Mineral Research. Honolulu, 22 (S1): S163, M159. (Conferences, Seminars and Symposiums: Conference Presentation) 2007
