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- Detailed Information
Lesley Davenport
Professor
Chemistry
Location: 344 Ingersoll Hall Extension
Phone: 718.951.5000 x2825
Fax: 718.951.4607
Email:
Lesley Davenport's Web site
Lesley Davenport has been professor at Brooklyn College since 1998. Previously, Davenport served as executive officer for the Biochemistry Ph.D. Program, CUNY Graduate Center (2002-08); visiting research scientist, NIH (1995-96); visiting research fellow, Paterson Institute for Cancer Research & Medical Oncology, United Kingdom (1988-90); visiting summer research fellow, University of Utrecht, the Netherlands (1988); associate/assistant professor, Brooklyn College (1985-97); and associate research scientist (1984-85) and postdoctoral research fellow (1981-83), The Johns Hopkins University.
Education:
Ph.D., University of Salford (United Kingdom) - 1981 (Biochemistry)
B.Sc. (honors), University of Salford (United Kingdom) - 1977 (Biochemistry)
Areas of Expertise:
Davenport's research in the laboratory focuses on studies of molecular interactions and fast conformational dynamics of large biomolecules. The lab uses state-of-the-art fluorescence spectroscopic methods. Funded through the Brooklyn College NIH-Score grant, they are currently using sensitive fluorescence methodologies to investigate the folding and stability of quadruplexed DNA found at the telomeric ends of chromosomes as an approach to designing better potential chemotherapeutics.
Doctoral Rotation Projects:
Students working in the laboratory will work as a member of a research team studying the dynamics and conformations of DNA G-quadruplexes. These structures are found within the telomeric DNA and inhibit telomerase, an enzyme that is important for tumorigenesis. The lab uses state-of-the art spectroscopic methods for studying conformations of complex biomolecules including fluorescence spectroscopy and circular dichroism. Students will also gain experience in modern biochemical lab methods, including experience in handling model DNA oligonucleotides.
Books and Publications
Kopkalli, Y., M. Zamadar, D. Aebisher, A. Greer and L. Davenport. "Studies of Quadruplex Folding Using a New Fluorescent Porphyrin Derivative." Biophysical Journal 100.3, Supplement 1: 234a. (Books and Publications: Abstract) 2011
Liu, S.X., Y. Kopkalli, A.V. Smirnov, J.R. Knutson and L. Davenport. "Fluorescence Studies of Local Environmental Heterogeneity Around Guanine Residues of the Telomeric DNA Quadruplex Conformation." Biophysical Journal 100.3, Supplement 1: 234a. (Books and Publications: Abstract) 2011
Kopkalli, Y., M. Chery, B.W. Willliams and L. Davenport. "Benzo[b]Fluorenone as a Quadruplex Interactive Agent (Qia): Binding Studies and Quadruplex Formation With the Human Telomeric HT4 Sequence." Biophysical Journal Supplement 98.3: 265a. (Books and Publications: Abstract) 2010
Liu, X., Y. Kopkalli, A.V. Smirnov, T. Rosales, M.E. Hawkins, J.R. Knutson and L. Davenport. "Local Dynamic Studies of Guanine Residues Within the Human Telomeric DNA G-Quadruplexed Conformation." Biophysical Journal Supplement 98.3: 265a. (Books and Publications: Abstract) 2010
Rosales, T., X. Liu, Y. Kopkalli, L. Davenport, M. Hawkins and J.R. Knutson. "G-Quadruplex Folding Observed by Two Photon Fluorescence Correlation Spectroscopy and Dual Time Scale." Biophysical Journal Supplement 98.3: 414a. (Books and Publications: Abstract) 2010
Liu, X., Y. Kopkalli and L. Davenport. "Conformational Stabilization of G-quadruplex DNA by Metalloporphyrins." Biophysical Society Meeting Abstracts, Biophysical Journal Supplement: 344a. (Books and Publications: Abstract) 2009
Liu, X.L., Y. Kopkalli, T. Vu, M.E. Hawkins and L. Davenport. "Conformational Stability of Fluorescently Labeled Human Telomeric G-Quadruplexed DNA Sequences." Biophysical Journal 94: 289a. (Books and Publications: Abstract) 2008
Martinez, A., Ch. S.K. Rajapakse, B. Naoulou, Y. Kopkalli, L. Davenport and R.A. Sanchez-Delgado. "The Mechanism of Antimalarial Action of the Ruthenium(II)-Chloroquine Complex [RuCl2(CQ)]2." Journal of Biological Inorganic Chemistry DOI 10.1007/s00775-008-0356-9. (Books and Publications: Peer Reviewed Article) 2008
Rosales, T., J. Xu, A.V. Smirnov, C. Combs, L. Davenport and J.R. Knutson. "Simultaneous Imaging of NAD+ and NADH Using CARS and 2-Photon Fluorescence Microscopy." Biophysical Journal 90S: 156a. (Books and Publications: Abstract) 2007
Davenport, L., A.V. Smirnov, C.A. Combs, K. Blinova, J.R. Knutson and R.S. Balaban. "Fluorescence Lifetime Imaging of NADH in Cells, in Solution and Encapsulated in Lipid Vesicles." Biophysical Journal 90S: 147a. (Books and Publications: Abstract) 2006
Jamison, J.L., L. Davenport and B. Williams. "Solvatochromic in the Aromatic Ketone Benzo(b)Fluorenone." Chemical Physics Letters 422: 30-35. (Books and Publications: Peer Reviewed Article) 2006
Kopkalli Y., M.J. Rosen and L. Davenport. "Interaction of N-Alkyl-2-Pyrrolidinone Surfactants with DMPC Lipid Bilayers." Biophysical Journal 90S: 505a. (Books and Publications: Abstract) 2006
Kopkalli, Y., M.J. Rosen and Lesley Davenport. "Interactions of N-alkyl-2-pyrrolidinone Surfactants with Dimyristoyilphosphatidylcholine Small Unilamellar Vesicles." Biophysical Journal 88, 70a, Abstract. (Books and Publications: Abstract) 2005
Kopkalli, Yasemin, Milton J. Rosen and Lesley Davenport. "Interactions of n-alkyl-2-pyrrolidinone Surfactants with Llipid Bilayers." Department of Chemistry, CUNY Graduate Center and Brooklyn College. Abstracts of Papers, 229th ACS National Meeting. San Diego, March 13-17, PHYS-489. Washington, D.C.: American Chemical Society. CODEN: 69GQMP Conference; meeting Abstract written in English. AN 2005:193605 CAPLUS (Copyright (c) 2006 ACS on SciFinder (R)). (Books and Publications: Abstract) 2005
Ramsook, C. and Lesley Davenport. "Effect of Guanidine Hydrochloride and Urea on the Conformation of BPAO." Bilophysical Journal 88, 38a, Abstract. (Books and Publications: Abstract) 2005
Voloshchuk, N., M.E. Hawkins and Lesley Davenport. "Mapping the DNA Binding Site of HIV-1 Integrase Using Fluorescent Oligonucleotides and Fluorescence Polarization." Biophysical Journal 88: 406a. (Books and Publications: Abstract) 2005
Awards, Honors and Fellowships
NIH-SCORE (SC3 GM095437-02), for "Conformation and Multimeric Formation of G-Quadruplexed DNA: Effects of Ligand Interactions." March 1, 2012 - Feb. 29, 2013. (Grants and Fellowships) 2012
NIH-SCORE (SC3 GM095437-01), for "Conformation and Multimeric Formation of G-Quadruplexed DNA: Effects of Ligand Interactions." March 1, 2011 - Feb. 29, 2012. (Grants and Fellowships) 2011
NIH-MBRS SCORE (1S06 GM060654 (076168)-010001), for "Conformational Stability and Dynamics of G-Quadruplexed DNA and Ligand Interactions." The specific aims of this project are: 1) to map the conformational stability at specific sites within the G-quadruplex and to assess the effects of QIA binding on these parameters; and 2) to examine the underlying dynamics of intramolecular G-quadruplex folding and unfolding. April 1, 2010-March 31, 2011. (Grants and Fellowships) 2010
NIH-MBRS SCORE (1S06 GM060654 (076168)-010001), for "Conformational Stability and Dynamics of G-Quadruplexed DNA and Ligand Interactions." The specific aims of this project are: 1) to map the conformational stability at specific sites within the G-quadruplex and to assess the effects of QIA binding on these parameters; and 2) to examine the underlying dynamics of intramolecular G-quadruplex folding and unfolding. April 1, 2009-March 31, 2010. (Grants and Fellowships) 2009
Broeklundian Professor, 2003-08. (Awards and Honors) 2008
Editorial board, Spectroscopy, 2000-present. (Awards and Honors) 2008
NIH-MBRS SCORE, (1S06 GM060654 (076168)-010001), for "Conformational Stability and Dynamics of G-Quadruplexed DNA and Ligand Interactions." The specific aims of this project are: 1) to map the conformational stability at specific sites within the G-quadruplex and to assess the effects of QIA binding on these parameters; and 2) to examine the underlying dynamics of intramolecular G-quadruplex folding and unfolding. April 1, 2008-March 31, 2009. (Grants and Fellowships) 2008
NIH-MBRS SCORE, (1S06 GM060654 (076168)-010001), for "Conformational Stability and Dynamics of G-Quadruplexed DNA and Ligand Interactions." The specific aims of this project are: 1) to map the conformational stability at specific sites within the G-quadruplex and to assess the effects of QIA binding on these parameters; and 2) to examine the underlying dynamics of intramolecular G-quadruplex folding and unfolding. April 1, 2007-March 31, 2008. (Grants and Fellowships) 2007
NIH-MBRS SCORE, (1S06 GM060654 (076168)-010001), for "Conformational Stability and Dynamics of G-Quadruplexed DNA and Ligand Interactions." The specific aims of this project are: 1) to map the conformational stability at specific sites within the G-quadruplex and to assess the effects of QIA binding on these parameters; and 2) to examine the underlying dynamics of intramolecular G-quadruplex folding and unfolding. April 1, 2006-March 31, 2007. (Grants and Fellowships) 2006
Outstanding Service Award, New York Section of the American Chemical Society (Awards and Honors) 2004
Outstanding Woman Scientist Award, New York Academy of Sciences and MetroSection of AWIS. (Awards and Honors) 2004
Chairwoman and Service Award, New York Section of the American Chemical Society. (Awards and Honors) 2003
Claire and Leonard Tow Professorship, 2000-02. (Awards and Honors) 2002
Conferences, Seminars and Symposiums
"Conformational Studies of G-Quadruplexed DNA." CUNY Structural Biology Workshop. June. (Conferences, Seminars and Symposiums: Invited Talk) 2011
"DNA Knots and Tumorigenesis: Folding and Conformation of Quadruplex-DNA." Institute of Biotechnology, St John's University. New York, September. (Conferences, Seminars and Symposiums: Invited Talk) 2011
Kopkalli, Y., M. Zamadar, D. Aebisher, A. Greer and L. Davenport. "Studies of Quadruplex Folding Using a New Fluorescent Porphyrin Derivative" poster. Annual Biophysical Society Meeting. (Conferences, Seminars and Symposiums: Conference Presentation) 2011
Liu, S.X., Y. Kopkalli, A.V. Smirnov, J.R. Knutson and L. Davenport. "Fluorescence Studies of Local Environmental Heterogeneity Around Guanine Residues of the Telomeric DNA Quadruplex Conformation" poster. Annual Biophysical Society Meeting. (Conferences, Seminars and Symposiums: Conference Presentation) 2011
"DNA Knots and Tumorigenesis: Folding and Conformation of Quadruplex-DNA." Chemistry Department, Bucknell University. Lewisburg, Pa., April. (Conferences, Seminars and Symposiums: Invited Talk) 2010
Kopkalli, Y., M. Chery, B.W. Willliams and L. Davenport. "Benzo[b]Fluorenone as a Quadruplex Interactive Agent (Qia): Binding Studies and Quadruplex Formation With the Human Telomeric HT4 Sequence" poster. Annual Biophysical Society Meeting. (Conferences, Seminars and Symposiums: Conference Presentation) 2010
Liu, X., Y. Kopkalli, A.V. Smirnov, T. Rosales, M.E. Hawkins, J.R. Knutson and L. Davenport. "Local Dynamic Studies of Guanine Residues Within the Human Telomeric DNA G-Quadruplexed Conformation" poster. Annual Biophysical Society. (Conferences, Seminars and Symposiums: Conference Presentation) 2010
Rosales, T., X. Liu, Y. Kopkalli, L. Davenport, M. Hawkins and J.R. Knutson. "G-Quadruplex Folding Observed by Two Photon Fluorescence Correlation Spectroscopy and Dual Time Scale." Annual Biophysical Society Meeting. (Conferences, Seminars and Symposiums: Contributed Talk) 2010
Chery, M., Y. Kopkalli, B.W. Williams and L. Davenport. "Formation and Stabilization of G-Quadruplex DNA Structures With Benzo[b]Fluorenone" poster. Annual ABRCM meeting. (Conferences, Seminars and Symposiums: Conference Presentation) 2009
Liu, X., Y. Kopkalli and L. Davenport. "Conformational Stabilization of G-quadruplex DNA by Metalloporphyrins" poster. Annual Biophysical Society Meeting. (Conferences, Seminars and Symposiums: Conference Presentation) 2009
Liu, X.L., Y. Kopkalli, T. Vu, M.E. Hawkins and L. Davenport. "Conformational Stability of Fluorescently Labeled Human Telomeric G-Quadruplexed DNA Sequences" poster. Annual Biophysical Society Meeting. Long Beach, Calif. (Conferences, Seminars and Symposiums: Conference Presentation) 2008
Professional Leadership
Panel discussant, CUNY Inspiring Woman Scientists Forum, September. (Professional Leadership: Public Service) 2010
Executive Officer, Biochemistry Ph.D. Program, CUNY Graduate Center, 2002-08. (Professional Leadership: Organizational Leadership Position) 2008
Councilor representing the New York Section, American Chemical Society, 2003-05. (Professional Leadership: Organizational Leadership Position) 2005
Affiliate member, National Committee on Science, American Chemical Society. (Professional Leadership: Committee Service) 2004
Chairwoman, New York Section of the American Chemical Society. (Professional Leadership: Organizational Leadership Position) 2002
Chairwoman, Biological Fluorescence Spectroscopy Subgroup, Biophysical Society. (Professional Leadership: Organizational Leadership Position) 1999
Other Professional Activities
Member, editorial board, Spectroscopy. 2011
Panel member, NIH Study Section, 2007-11. 2011
